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Antibiotx > All > Flashcards

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1
Q

Natural PCNs

A

V, G

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2
Q

Anti-Staph PCNs

A

Nafcillin
Oxacillin
Dicloxacillin

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3
Q

AminoPCNs

A

Ampicillin

Amoxicillin

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4
Q

Anti-PseudomonalPCNs

A

Ticarcillin

Piperacillin

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5
Q

1st gen cephalosporins

A

Cefazolin

cephalexin

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6
Q

2nd gen cephalosporins

A

cefoxitin

cefuroxime

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7
Q

3rd gen cephalosporins

A

ceftriaxone

ceftazidime

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8
Q

4th gen cephalosporins

A

cefepime

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9
Q

Carbapenems

A

imipenem/cilastatin
meropenem
ertapenem

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10
Q

B-lactamase inhibitors

A

ampicillin-sulbactam
amoxicillin-clavulonic acid
piperacillin-tazobactam

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11
Q

glycopeptides

A

vancomycin

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12
Q

fluoroquinolones

A

ciprofloxacin
levofloxacin
moxifloxacin

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13
Q

aminoglycosides

A

amikacin
tobramycin
gentamycin

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14
Q

Tetracyclines/glycyclines

A

minocycline
doxycycline
tigecycline

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15
Q

macrolides/ketolides

A

clarithromycin
azithromycin
telithromycin

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16
Q

lincosamides

A

clindamycin

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17
Q

oxazolidinones

A

linezolid

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18
Q

CURB-65

A

confusion
Uremia (BUN>19)
Resps (>30)
BP (4000, plt > 100000, temp> 36

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19
Q

Cell Wall inhibitors

A 
Cephalosporins
Carbapenems
Glycopeptides
Monobactams
PCNs
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20
Q

Monobactam

A

Aztreonam

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21
Q

DNA replication inhibitors

A

Flouroquinolones

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22
Q

Protein Synth Inhibitors 30S

A

Aminoglycosides

tetracyclines

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23
Q

Protein synth inhibitors 50S

A

clindamycin
linezolid
macrolides
streptogramins

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24
Q

Natural PCNs admin

A

G-IV, IM

V-PO

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25
Q

Anti-staph PCN admin

A

nafcillin-IV, IM
Oxacillin-IV, IM
dicloxacillin-PO

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26
Q

AminoPCN admin

A

Ampicillin-PO, IV, IM

Amoxicillin-PO

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27
Q

Anti-pseudomonalPCN admin

A

IV

28
Q

Cephalosporin 1st gen admin

A

cefazolin-IV, IM

Cephalexin-PO

29
Q

Cephalo 2nd gen admin

A

cefoxtin-IV

Cefuroxime-PO, IV, IM

30
Q

cephalo 3rd gen admin

A

ceftriaxone-IV, IM

Ceftazidime-IV, IM

31
Q

cephalo 4th gen admin

A

cefepime-IV, IM

32
Q

Carbapenems admin

A

imipenem/cilastatin-IV
meropenem-IV
ertapenem-IV, IM

33
Q

Monobactam admin

A

aztreonam-IV, IM, INH

34
Q

B Lactamase inhib admin

A

ampicillin/sulbactam-IV
amoxicillin-clavulanic acid-PO
Piperacillin/tazobactam-IV

35
Q

glycopeptide admin

A

vancomycin-PO, IV

36
Q

FQ admin

A

PO, IV, Topical

37
Q

Aminoglycosides admin

A

amikacn-IV, IM
Tobramycin-Iv, IM, IN, Topical
gentamycin-IV, IM, Topical

38
Q

Tetracyclines admin

A

minocycline-PO, IV
doxycycline-PO, IV
tigecyclin-IV

39
Q

Macrolides admin

A

larithromycin-PO
azithromycin-PO, IV, Topical
telithromycin-PO

40
Q

LIncosamides admin

A

clindamycin-PO, IV, IM, opical

41
Q

Oxazolidinones admin

A

linezolid-PO, IV

42
Q

No renal dose adjustgin

A

ceftriaxone

moxifloxacin

43
Q

PCN MOA/R

A

inhibits cell wall synth

R: b lactamases, changes in PBPs

44
Q

PCN SE

A

allergic rxns, GI, pseudomemb colitis, nephritis

45
Q

cephalosporins MOA/R

A

cell wall synth

R: b lactamases, changes in PBPs

46
Q

Cephalosporin Se

A

diarrhea, iintolerance to alcohol, cross reactivity to PCNs

47
Q

Carbapenems MOA/R

A

cell wall synth

R” KPC carbapenemase

48
Q

Carbapenems SE

A

N/V
seizures
hypersensitivity

49
Q

Monobactam MOA/R

A

cell wall synth

R: b lactamases, changes in PBPs

50
Q

Monombactam use

A

allergy to PCN, cephalosporings

51
Q

Glycopeptides MOA/R

A

cell wall synth

52
Q

Glycopeptides SE

A

rash, red man syndrome, ototox, nephrotox

53
Q

FQ MOA/R

A

DNA gyrase
R: no FQ modifying/inactivating entities
mutation in DNA gyrase/topoisomerase

54
Q

FQ SE

A

NVD
CNS
Rash, photosensitivity
Achilles tendon rupture kids

55
Q

Don’t give to kids

A

FQ, tetracyclines

56
Q

aminoglycosides MOA/R

A

30s, conc dependent

R; AG metabolizing enzymes, impaired trx of drug into cell, altered ribosome

57
Q

aminoglycosides SE

A

ototox, nephrotox, neuromuscular block, apnea

58
Q

Tetracyclines MOA/R

A

30s

R: dec influx, acquisition energy dep efflux, ribosomal protection proteins, enzymatic inactivation

59
Q

Tetracyclines SE

A

GI, c diff superinfx, photosens, teeth discoloration, thrombophlebitis

60
Q

Macrolides MOA/R

A

50s

R: drug efflux, ribosomal protection proteins, hydrolysis, ribosomal mutations

61
Q

macrolides Se

A

Gi, hepatotox, arryhtmia, QT prolong

62
Q

Lincosamides MOA/R

A

50s

R: ribosomal methylation

63
Q

Licosamides Se

A

GI diarrhea, pseudomemb colitis (c dif), rash, inc ALTs, potentiate neuromusc block

64
Q

Oxazolidinones MOA/R

A

50s

R: ribosomal mutation

65
Q

Oxazolidinones Se

A

myelosuppression, GI, HA rash

66
Q

Oxazolidinones drug intrx

A

SSRI

Antibiotx (3 decks)

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