Antivirals Flashcards

1
Q

Recall the type of genome in HIV

A

Single positive sense strand RNA (it is a retrovirus)

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2
Q

Recall the type of genome in hepatitis B

A

dsDNA

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3
Q

Recall the type of genome in hepatitis C

A

ssRNA

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4
Q

Recall the type of genome in HSV

A

DNA

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5
Q

Recall the type of genome in influenza

A

RNA

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6
Q

Which serotypes of hepatitis carry risk of chronic infection, and what are the consequences of this?

A

Hep B and C

Liver cirrhosis, hepatocarcinoma

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7
Q

For which hepatitis vaccine is there a vaccine available?

A

Hep B

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8
Q

Summarise the life cycle of HIV, naming relevant molecules and proteins

A
  1. GP120 binds CD4/CCR5/CXCR4
  2. Virus enters via GP41
  3. Genome replicated in cytoplasm via RT
  4. DNA integrated into host genome by integrase
  5. Host cell machinery produces viral proteins, via cleavage of Gag precursor by HIV protease
  6. Viral assembly
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9
Q

Recall the disease state related to HSV1 and 2

A
HSV1 = cold sores
HSV2 = genital herpes
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10
Q

Summarise the escape of the influeza virus from each host cell

A

Uses neuraminidase to cleave sialic acid in membrane

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11
Q

Recall 2 drugs that inhibit HIV attachment and entry and their MOA

A

Enfuvirtide (binds GP41)

Maravirov (blocks CCR5)

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12
Q

Recall 3 classes of drug that inhibit HIV genome replication, and give an example of a drug within each

A

Nucleoside RT inhibitors: zidovudine
Nucleotide RT inhibitors: tenofovir
Non-nucleoside RT inhibitors: efavirenz

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13
Q

Recall an example of a drug that inhibits integration of HIV genetic material into the host genome, and its MOA

A

Raltegravir

Integrase inhibitor

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14
Q

Recall the MOA of saquinivir as an antiviral, and what it is coadministered with

A

HIV protease inhibitor

Coadministered with ritonavir to slow FPM of saquinivir

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15
Q

Which antiviral drug is used for HSV and what is its MOA

A

Acyclovir

Nucleoside analogues

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16
Q

Which antiviral drug is used for influenza and what is its MOA

A

Oseltamivir

Neuraminidase inhibitor