Antivirals

Question 1

Binds CCR5 to prevent HIV from entering cell

Answer 1

Maraviroc

Question 2

Binds HR1 to prevent HIV from entering cell

Answer 2

Efuvirtide

Question 3

Block M2 ion channels to prevent acidification needed to release influenza virus into cell

Answer 3

Ramantadine & Amantadine

Question 4

Competitive inhibitors of dGTP used to treat of hepatitis, varicella, and cytomegaloviruses

Answer 4

Gangciclovir (valgangciclovir)
Acyclovir (valacyclovir)

• activated by VIRAL kinases

Question 5

Nucleoside inhibitors of HIV (competitive nucleoside inhibitors)

Answer 5

Abacavir
Lamivudine
Tenofovir disproxyl 
Zidovudine
emtricitabine 

• activated by Host kinases

Question 6

Toxicities of NRTIs

Answer 6

Pancreatitis
Peripheral neuropathy
Myopathy
Anemia
Granulocytopenia

Question 7

NNRTIs of HIV-1 that bind to p66 subunit of reverse transcriptase

Answer 7

Nevirapine & Efavirenz

Question 8

pyrimadine analog that acts as an irreversible inhibitor of Tymidylate Synthatase for HSV

Answer 8

Trifluridine

Question 9

Integrase inhibitor of HIV that prevents integration of HIV genome into host’s

Answer 9

Raltegravir

Question 10

Protease inhibitors of HIV-1 that prevents cleavage of non-structural and structural proteins

Answer 10

Ritonavir *CYP3A4 inhibitor

Atazanavir

Question 11

Protease inhibitors of Hepatitis C that prevent formation of non-structural proteins

Answer 11

Boceprevir

Telaprevir

Question 12

Protein synthesis inhibitor for Hepatitis

Answer 12

Peginterferon

Question 13

Inhibitors of influenza release

Answer 13

Zanamivir

Oseltamivir

Question 14

pyrophosphate analog that inhibits RNA and DNA pol and also HIV reverse transcriptase

Answer 14

Foscarnet

*works for HIV, HSV & HBV