Antivirals

Question 1

Drug Class: Antiviral or Antiretroviral? Sub-class? Acyclovir (Val-)

Answer 1

Antiviral - Nucleic Acid Synthesis by Herpse Viruses

Question 2

Drug Class: Antiviral or Antiretroviral? Sub-class? Boceprevir

Answer 2

Antiviral - Cleave of Precursor Polypeptides of HCV (NS3/4A protease)

Question 3

Drug Class: Antiviral or Antiretroviral? Sub-class? Foscarnet

Answer 3

Antiviral - Non-given

Question 4

Drug Class: Antiviral or Antiretroviral? Sub-class? Ganciclovir (Val-)

Answer 4

Antiviral - Nucleic Acid Synthesis by Herpse Viruses

Question 5

Drug Class: Antiviral or Antiretroviral? Sub-class? Oseltamivir

Answer 5

Antiviral - Neuroamidase - release of Influenza virus from infected cell

Question 6

Drug Class: Antiviral or Antiretroviral? Sub-class? Ribavarin

Answer 6

Antiviral - Competitively inhibits GTP-dependent 5? capping of viral messenger RNA and specifically influenza virus transcriptase activity

Question 7

Drug Class: Antiviral or Antiretroviral? Sub-class? Telaprevir

Answer 7

Antiviral - Cleave of Precursor Polypeptides of HCV

Question 8

Drug Class: Antiviral or Antiretroviral? Sub-class? Trifluridine

Answer 8

Antiviral - A fluorinated pyrimidine nucleoside that irreversibly inhibits thymidylate synthase and specific DNA polymerases, thus inhibiting DNA synthesis.

Question 9

Drug Class: Antiviral or Antiretroviral? Sub-class? Zanamivir

Answer 9

Antiviral - Neuroamidase - release of Influenza virus from infected cell

Question 10

Drug Class: Antiviral or Antiretroviral? Sub-class? Abacavir

Answer 10

Antiretroviral - Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Question 11

Drug Class: Antiviral or Antiretroviral? Sub-class? Lamivudine (3-TC)

Answer 11

Antiretroviral - Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Question 12

Drug Class: Antiviral or Antiretroviral? Sub-class? Tenofovir Disoproxil

Answer 12

Antiretroviral - Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Question 13

Drug Class: Antiviral or Antiretroviral? Sub-class? Zidovudine (AZT)

Answer 13

Antiretroviral - Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Question 14

Drug Class: Antiviral or Antiretroviral? Sub-class? Emtricitabine

Answer 14

Antiretroviral - Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Question 15

Drug Class: Antiviral or Antiretroviral? Sub-class? Didanosine (ddI)

Answer 15

Antiretroviral - Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Question 16

Drug Class: Antiviral or Antiretroviral? Sub-class? Stavudine (D4T)

Answer 16

Antiretroviral - Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Question 17

Drug Class: Antiviral or Antiretroviral? Sub-class? Efavirenz

Answer 17

Antiretroviral - Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)

Question 18

Drug Class: Antiviral or Antiretroviral? Sub-class? Nevirapine

Answer 18

Antiretroviral - Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)

Question 19

Drug Class: Antiviral or Antiretroviral? Sub-class? Atazanavir

Answer 19

Antiretroviral - HIV-1 Protease Inhibitor

Question 20

Drug Class: Antiviral or Antiretroviral? Sub-class? Ritonavir

Answer 20

Antiretroviral - HIV-1 Protease Inhibitor

Question 21

Drug Class: Antiviral or Antiretroviral? Sub-class? Enfuvirtide

Answer 21

Antiretroviral - Fusion Inhibitor

Question 22

Drug Class: Antiviral or Antiretroviral? Sub-class? Maraviroc

Answer 22

Antiretroviral - Fusion Inhibitor

Question 23

Drug Class: Antiviral or Antiretroviral? Sub-class? Raltegravir

Answer 23

Antiretroviral - DNA Strand Transfer Inhibitor

Question 24

Mechanisms of Action - Adefovir

Answer 24

Competitive inhibitor of viral DNA polymerases and reverse transcriptases with respect to deoxyadenosine triphosphate.

Question 25

Mechanisms of Action - Entecavir

Answer 25

Competitive inhibitor of HBV DNA polymerase with respect to deoxyguanosine triphosphate.

Question 26

Mechanisms of Action - Lamivudine

Answer 26

Competitively inhibits HBV DNA polymerase, causing chain termination.

Question 27

Mechanisms of Action - Telbivudine

Answer 27

Competitive inhibitor of HBV DNA polymerase with respect to Thymidine 5?- triphosphate.

Question 28

Mechanisms of Action - Ribavirin

Answer 28

Incompletely understood, but Competitively inhibits GTP-dependent 5? capping of viral messenger RNA and specifically influenza virus transcriptase activity.

Question 29

Mechanisms of Action - Trifluridine

Answer 29

A fluorinated pyrimidine nucleoside that irreversibly inhibits thymidylate synthase and specific DNA polymerases, thus inhibiting DNA synthesis.

Question 30

Mechanisms of Action - Integrase Inhibition

Answer 30

Prevent HIV Integrase from encoding viral DNA into host chromosome

Question 31

Mechanisms of Action - HIV-1 Protease Inhibitors

Answer 31

Prevent cleavage of HIV gag and pol precursor polypeptides

Question 32

Mechanisms of Action - Boceprevir and Telaprevir

Answer 32

Prevent HCV polyprotein from being cleaved by the NS3/4a (Serine) proteases

Question 33

Mechanisms of Action - Protein synthesis Inhibition (PEGInterferon)

Answer 33

Inhibition of Transcription, translation, post-translational proccressing, and virus maturation

Question 34

Mechanisms of Action - Neuraminidase

Answer 34

Prevent virus fusion with cell membrane to EXIT host membrane

Question 35

Mechanisms of Action - NNRTIs

Answer 35

Bind to p66 subunit of HIV-1 that causes a CONFIRMATIONAL change. Do not require intracellular phosphorylation

Question 36

Mechanisms of Action - NRTIs

Answer 36

Converted to triphosphase nucleotides and compete for endogensous nucleosides. Does not bind directly to the reverse transcriptase (like the NNRTIs)

Question 37

Mechanisms of Action - “-cyclovirs”

Answer 37

Competively inhibits dGTP, incorporated into growing chain, traps polymerase on special nucleotide