Antivirals

Question 1

Lepidsavir-sofosbuvir

Answer 1

Hepatitis C RNA polymerase

Question 2

Pleconaril

Answer 2

Picornavirus VP proteins

Question 3

Lamivudine

Answer 3

Reverse transcriptase (nucleotide analog) for hepatitis B and HIV

Question 4

Oseltamivir

Answer 4

Influenza virus neuraminadase

Question 5

Ribavirin

Answer 5

RNA-dependent RNA-polymerase (nucleotide analog) for RSV

Question 6

Acyclovir

Answer 6

Herpes thymidine kinase (nucleotide analog), inhibits viral polymerase

Question 7

Maraviroc

Answer 7

CCR5 on human cells, treats HIV

Question 8

Saquinavir

Answer 8

HIV protease

Question 9

Nevirapine

Answer 9

Reverse transcriptase (directly) for HIV

Question 10

Cidofovir

Answer 10

Poxvirus and papillomavirus DNA polymerase

Question 11

Amantadine and Rimantidine

Answer 11

Influenza virus M2 (matrix) protein, prevents uncoating

*not currently prescribed due to development of drug resistant strain

Question 12

Imiquimod

Answer 12

TLR-7 agonist, stimulating type 1 interferon release

Question 13

Tecovirimat

Answer 13

poxvirus envelopment

Question 14

Penciclovir

Answer 14

inhibits HSV and VZV by targeting thymidine kinase

Question 15

Ganciclovir

Answer 15

targets protein kinase UL97 of CMV

Question 16

Valganciclovir

Answer 16

prodrug for CMV given for 6 months orally

Question 17

Palivizumab

Answer 17

monoclonal antibody against RSV F protein

very expensive

Question 18

Zanamivir (Relenza)

Answer 18

neuraminidase inhibitor prevents viral release, orthomyxovirus (influenza)

Question 19

Molnupiravir

Answer 19

coronavirus, recognized as C or U–> mutations in viral replication cycle

Question 20

Paxlovid (Nirmatrelvir+Ritonavir)

Answer 20

coronavirus, targets protease

Question 21

Baricitinib

Answer 21

coronavirus JAK inhibitor

Question 22

Tocilizumab and Sarilumab

Answer 22

anti-IL6 receptor