Antiviral mechanism of action

Question 1

Cidofovir ?

Answer 1

Nucleoside phosphonate inhibiting CMV DNA polymerase.

Question 2

Aciclovir ?

Answer 2

A nucleoside analogue .
It competitively inhibits the viral DNA polymerase.

Question 3

Ganciclovir ?

Answer 3

Nucleoside analogue
It is also phosphorylated in non-infected cells causing toxicity.

Question 4

Valaciclovir and valganciclovir

Answer 4

Prodrugs of aciclovir and ganciclovir respectively, but have improved oral bioavailability

Question 5

Lamivudine
3TC

Answer 5

Nucleoside analogue which inhibits the reverse transcriptase activity of the hepatitis B virus polymerase.

Question 8

Ribavirin

Answer 8

1- depletion of guanine nucleotides through inhibition of inosine monophosphate dehydrogenase (IMPDH).
2- interference with RNA capping & polymerases

Question 9

Oseltamivir
(Tamiflu) ?

Answer 9

Inhibits influenza neuraminidase by occupying catalytic site.

Question 10

Foscarnet ?

Answer 10

Pyrophosphate analogue which inhibits viral DNA polymerase

Question 11

Amantidine, rimantidine

Answer 11

Prevent viral uncoating of influenza A by blocking the membrane protein M2 ion channel

Question 12

T/F :
cobicistat Can be used safely with rifabutin.

Answer 12

F
Cobicistat can not be used with rifampicin or rifabutin
—
can use rifabutin instead of rifampicin when ritonavir is used