antipsychotics pt 2 Flashcards
First Gen antipsychotics
typical antipsychotic medication
typical antipsychotics
have an affinity for dopamine receptors. They are effective in treating positive symptoms because they are potent dopamine antagonists in the moesolimbic pathway
typical antipsychotic side effects
caused because they are potent dopamine antagonists in the other brain pathways
2 subcategories of typical antipsychotics
phenothiazines
- aliphatic
- piperidine
- piperazine
nonphenonthiazines
- Thioxanthenes
- dibenzoxapine
- butyropheone
relationship of dopamine and prolactin release
Dopamine restrains prolactin production, so the more dopamine there is, the less prolactin is released from anterior pituitary gland
mesolimbic effects in typical antipsychotics
+ symptoms, > in dopamine
mesocortical and typical antipsychotics
- symptoms and cognitive ( hypo function of pathway)
nigostriatal and typical antipsychotics
EPSE/TD contains 80% of brains dopamine
Tuberoinfundibular in Typ antipsych
endocrine and prolactin release
dopamine and Acetylcholine relationship
dopamine inhibits the release of acetylcholine (ACh) from nerve terminals of caudate cholinergic interneurons
decrease dopamine= increase in ACh
chlorpromazine
brand name: Thorazine, Largactil, CPZ
chem class:Phenothiazine (aliphatic)
potency: low
oral dosage: 25-1000mg/ day
methotrimeprazine
brand name: Nozinan
chem class: Phenothiazine aliphatic
potency: low
oral dosage: 10-200mg/ day
what should you note about aliphatic phenothiazines
they are more likely to produce postural hypotension and sedation than other drugs
methotrimeprazine is used as sleep aid at low doses
what is the prototype phenothiazine
chlorpromazine
piperidine phenothiazine
( pericyazine)
brand name:neuleptil
chem class: phenothiazine ( piperidine)
potency: high
oral dosage: 5- 60mg/day
