Antipsychotics + CNS stimulant

Question 1

Typical antipsychotics (1st gen)

Answer 1

-Thorazine (chlorpromazine): sedating
-Haldol (haloperidol)
-sedating, strong anticholinergic

Adverse effects:
-early: neuroleptic malignant syndrome-fever and unstable vitals, high lethality, needs ICU care
-mid-range: extrapyramidal symptoms
-late: tardive dyskinesia, involuntary movements such as grimacing and eye blinking, can be permanent

treatment for adverse effects: antihistamine- Benadryl (diphenhydramine), Vistaril (hydroxyzine); Cogentin (benztropine)

Question 2

Atypical antipsychotics (2nd gen)

Answer 2

-Clozaril (clozapine): can cause agranulocytosis
-Risperdal (risperidone)
-Seroquel (quetiapine): can be sedating
-abilify (aripiprazole): also use for MDD and Bipolar
-Zyprexa (olanzapine): can cause metabolic syndrome and weight gain

-EPS, TD, and anticholinergic side effects less common
Block Warning: increased risk of death in older adults with dementia

Adverse effects: dry mouth, constipation, increased appetite, weight gain, extrapyramidal symptoms, higher risk of metabolic effects compared to 1st gen

Question 3

ADHD meds- CNS stimulant (methylphenidate)

Answer 3

side effects:
-CNS stimulation
-weight loss due to decrease appetite
-cardiovascular= dysthymias, chest pain, high BP
-develop psychotic manifestations
-withdrawal= HA, n/v, muscle weakness, depression
-hypersensitivity= hives, papules
-toxicity= dizziness, palpitations, HTN, hallucinations, seizures