AntiPsychotics

Question 1

First generation - low potency

Answer 1

Chlorpromazine, Chlorprothixena, Levomepromazine, Promethazine, Thioridazine, Zuclopenthixole

Question 2

First generation - high potency

Answer 2

Flupenthixol, fluphenazine, haloperidol, perphenazine

Question 3

Second generation antipsychotics

Answer 3

aripiprazole, clozapine, olanzapine, quetiapine, risperidone, ziprasidone

Question 4

Depot antipsychotics

Answer 4

dlupenthixol decanoate, fulphenazine decanoate, haloperidol decanoate

Question 5

mood stabilizers

Answer 5

Lithium salts, valproic acid, carbamazepine, lamotrigine

Question 6

Antipsychotics

Answer 6

symptomatic drugs, schizophrenia, maniacal psychosis, agitation, bipolar, antiemetics (rare, small doses)

Question 7

PRescriptions

Answer 7

written only by specialist, establishes diagnosis, utility, cardiac thyroid and renal function during treatment response, compliance, side effects, drug interactiosn

Question 8

Routes

Answer 8

orally, tablets, dissolvable (great bioavailability, high cost hospital), intravenously, intramuscularly (emergencies)

Question 9

Therapeutic doses

Answer 9

chosen according to severity of disease, tolerance, individual response to treatment,

Question 10

Effect

Answer 10

appears gradually, after 3 weeks max after 2-6 months

Question 11

Retard antipsychotics

Answer 11

IM, 2-4 weeks, controlled administration, administered after period of oral administration (prevent allergy)

Question 12

First generation SE

Answer 12

extrapyramidal, sedation, increased prolactin (gynecomastia, menstrual irregularities, amenorrhea, reduced libido, impotence), arrhythmia, agranulocytosis, anticholinergic (xerostomia, constipation, urinary retention, increased ICP, allergy), neuroleptic malignant syndrome (life threatening).

Question 13

Second generation SE

Answer 13

no EP, metabolic disorders (obesity, diabetes, hyperlipidemia)

Question 14

Compliance

Answer 14

low, because of side affects, daily administration, forget/feel well/miss hearing voices

Question 15

Antipsychotic contraindications

Answer 15

alcohol, antidepressant, hypnotics, analgesic intoxication, Parkinson, seizures, glaucoma, prostate adenoma

Question 16

Promethazine

Answer 16

antihistaminic drug without antipsychotic properties, sedative used in psychomotor agitation

Question 17

Lithium salts

Answer 17

mood stabilizers, old, mechanism uncertain, prevents suicide, low therapeutic index(1) , close monitoring, adverse effects are frequent, tremor (test lithium level), nephrotoxicity (creatinine), diabetes insipidus (electrolytes), hypothyroidism (test TSH level), Ebstein anomaly (pregnancy)

Question 18

Together with pharmacological treatment

Answer 18

we use psychotherapy, ergo therapy, melotherapy, sociotherapy

Question 19

Abrupt discontinuation

Answer 19

relapse, acute symptoms

Question 20

Treatment will involve

Answer 20

active collaboration with family