Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHARM II FINAL > Antipsychotics > Flashcards

Antipsychotics Flashcards

1
Q

List of first generation antipsycholtics

A 
Haloperidol --- Haldol
Fluphenazine -- Prolixin
Perphenazine -- Trilafon
Thioridazine -- Mellaril
Chlorpromazine -- Thorazine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MOA of First Gen Antipsychotics

A

D2 Receptor Antagonists (reduces dopamine)

can induce low-dopamine sx
(dystonia, diskinesia, parkinson like stuff)

5-HT2 receptor antagonist (weight gain)

Unique to 1st gen:
Alpha 1 antagonist (Sedation)
H1 antagonist (sedation, weight gain)
M1 antagonist (anticholinergic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which MOA receptors in 1st ten antipsychotics contribute to weight gain

A

5-HT2 receptor antagonists

H1 antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

2nd Gen Antipsychotic Drugs

A

Aripriprazole - Abilify***
Brexpriprazole - Rexulti

Asenapine - Saphris
Clozapine - Clozaril
Olanzapine - Zyprexa
Quetiapine - Seroquel***

Iloperidone 
Lurasidone 
Paliperidone - Invega
Risperidone - Risperidol***
Ziprasidone -
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Benefit of 2nd gen antipsychotics

A

Antipsychotic effects without ANTIPYRAMIDAL effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

2nd Gen Antipsychotic MOA

A

D2 receptor Antagonist (antipsychotic effect, relief pos symptoms)

5-HT1 receptor antagonist (antidepressant)
5-HT2 receptor antagonist (negative symptom improvement)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

5-HT2 receptor antagonist effects

A

Weight gain

Negative symptom improvement (apathy, social withdrawal)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Drug to treat tar dice dyskinesia

A

Valbenazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Antipsychotic black box

A

Increased mortality in elderly w dementia psychosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Clozapine warning

A

Agranulocytosis

Myocarditis, bradyardia

Orthostasis

Avoid P450 / 3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Interesting positie side effect of Clozapine

A

Decreased cigarette smoking

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Drug specifically indicated for schizophrenia

A

Iloperidone

Paliperidone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Indicated for acute treatment of manic or mixed episodes, bipolar - acute schizo problems

A

Asenapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Lithium indications

A

1st line for manic bipolar episodes and maintenance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Lithium contraindications

A

Renal or CV disease

Dehydration, sodium depletion

Patients receiving diuretics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Lithium warnings

A

Pregnancy - teratogenic

Renal toxicity

17
Q

Diarrhea, vomitting, drowsy, muscle weakness, lack or coordination are early signs of

A

Lithium toxicity

18
Q

High level lithium toxicity symptoms

A 
Giddiness
Ataxia
blurred vision
tinnitus
large output dilute urine

PHARM II FINAL (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions