Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHARM II FINAL > Antidepressants / Anxiolytics > Flashcards

Antidepressants / Anxiolytics Flashcards

1
Q

Best antidepressants

A

Prozac (fluoxetine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

SSRIs

A

Prozac

Paxil

Celexa

Lexapro

Zoloft

Luvox

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

SNRIs

A

Effexor

Pristiq

Cymbalta

Savella

Fetzima

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Tricyclic

A

Amitriptyline (Elavil)

Imipramine (Tofranil)

Desipramine

Doxepin (Sinequaan)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MAOIs

A

Nardil

Marplan

Parnate

Selegiline (Eldepryl)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Serotonin / 5HT Modulators

A

Trazodone

Vilazodone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Atypicals

A

Wellbutrin (Buproprion)

Remeron (Mirtazapine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which antidepressants have an increased bleeding risk

A

SSRI

Prozac
Paxil
Celexa
Lexapro
Zoloft
Luvox

interferes with platelet activation / aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which SSRIs are 2D6 2C9 inhibitors?

A

Zoloft and Paxil

watch out for Rifampicin and Warfarin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

SSRI’s and pregnancy

Prozac
Paxil
Celexa
Lexapro
Zoloft
Luvox
A

Not Great

1st trimester - cardiac defects

3rd trimester - low birth weight, premature, withdrawal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

SSRI least associated with weight gain

A

Prozac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

SSRII general indications

A 
MDD
OCD
PD
Bulimia 
GAD
SAD
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SSRI with highest risk of drug interactions

A

Paxil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

SSRI that is most sedating, most weight gain, most sexual dysfunction

A

Paxil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which SSRI is also indicated for PTSD, PMDD

A

Zoloft

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

SSRI with few drug interactions and lowest sexual side effects

A

Celexa

for dep

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Limits of using Celexa

A

Only really indicated for depression, no other psych probe

risk of QT prolongation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which SSRI would be most appropriate for a patient who has depression and CV

A

Zoloft

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which SSRI is indicated also for PD

A

Zoloft

Prozac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Which SSRIs are not indicated for anxiety

A

Prozac

Celexa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

SSRI with widest scope of indications

A

Zoloft

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

SNRI MOA

Effexor
Pristiq
Cymbalta
Savella
Fetzima
A

Binds 5-HT and NE receptor transporters

23
Q

In addition to depression and anxiety disorders, what can SNRI’s be used for?

Effexor
Pristiq
Cymbalta
Savella
Fetzima
A

Neuropathic pain, chronic pain
(Cymbalta, Effexor)

Fibromyalgia
(Savella)

24
Q

2 ADRs of SNRIs which are not found in SSRI

A

Hypertension

Hyperlipidemia

25
Q

SNRI drug interactions

Effexor
Cymbakta
Savella
Fetzima
Pristiq
A

Platelet inhibitors

MAOIs

26
Q

Which SNRIs is a strong 3A4 inhibitor

A

Levomilnacipram (Fetzima)

Watch

Benzo's
CCB's
Macrolides
HIV antivirals
Statins
27
Q

Which SNRIs are strong 2D6 inhibitors

A

Cymbalta

28
Q

Which SNRI is really only indicated for MDD

A

Pristiq

29
Q

Effexor used for

A

PTSD, neuropathic pain, hot flashes

30
Q

Avoid using Cymbalta with these patients

A

Renal, hepatic impairment

31
Q

Savella is only really indicated for

A

FIBROMYALGIA

32
Q

MOA of Remeron vs MOA of Wellbutrin

A

Remeron increase 5HT and NE centrally

Wellbutrin is a WEAK NE reuptake inhibitor, does not effect 5HT

33
Q

Indications of Remeron vs Wellbutrin

A

Remeron - MDD

Wellbutrin - MDD and Smoking Cessation

34
Q

Wellbutrin UP ADRs

A

more UP

Anxiety, Insomnia, Psychosis

Weight loss
Hypertension
Dry Mouth

35
Q

Remeron DOWN ADRs

A

more DOWN

Sedation
Dizzy
Weight gain

High cholesterol, High LFTs

36
Q

What even is a Tricyclic ??

Amitriptyline (Elavil)
Imipramine (Tofranil)
Desipramine
Doxepin (Sinequaan)

A

SNRI with alpha adrenergic block

37
Q

Tricyclic effect on the heart?

Amitriptyline (Elavil)
Imipramine (Tofranil)
Desipramine
Doxepin (Sinequaan)

A

Membrane stabilizing effect - blocks sodium channels

anti arrhythmic?

38
Q

In addition to depression, anxiety, ocd, what can tricylic be used for?

A

Neuropathic pain
Migraine
Bipolar

39
Q

Tricyclic interactions

Amitriptyline (Elavil)
Imipramine (Tofranil)
Desipramine
Doxepin (Sinequaan)

A

Cimetidine

MAOIs, Sympathomimetics, Antocholinergics, SSRIs

2D6

40
Q

Tricyclic ADR

Amitryptyline
Imipramine
Desipramine
Doxepin

A

Anticholinergic

Arrhythmia

Sexual disfunction

Diaphoresis

41
Q

Tricyclics OD risk

Amitryptaline
Imipramine
Desipramine
Doxepin

A

HIGH RISK - 70% mortality, 10 days supply taken at once can be fatal

42
Q

5HT modulators ADRs

Trazodone
Vilazodone

A

Sedation, somnolence

HA, Dizziness, dry mouth

ARRYTHMIA, LONG QT, ORTHOSTASIS

43
Q

Vilazodone indication

A

Depression

44
Q

Trazodone indication

A

Depression

Low doses for sleep

45
Q

WATCH OUT VILAZODONE IS A

A

P450 3A4 SUBSTRATE

46
Q

WEIRD VILAZODONE ADR

A

PRIAPSISM

47
Q

MAOI contraindication

A

HTN / CV disease

Amphetamines, Sympathomimetics

CNS depressants (alcohol, narcotics)

Antihypertensive, Diuretic, Antihistaminic, Sedative, Anesthetic drugs

Buproprion, Dextromethorphan

CHEESE

48
Q

APA guidelines for treating depression 1st line

A

1st line: SSRI, SNRI,

Buproprion (Wellbutrin) Mirtazepine (Remeron)

49
Q

1st line for GAD

A

Paxil
Lexapro

Effexor
Cymbalta

50
Q

2nd line for GAD

A

Buspirone

  • partial agonist of 5HT receptors
  • no dependency
  • no sedation
  • slow onset
  • not effective for depression

ADRs
- dizzy, HA, nausea

51
Q

1st line OCD

A

SSRIs

Prozac
Paxil
Celexa
Lexapro
Zoloft
52
Q

1st line for SAD

A

Effexor

SSRIs
Prozac
Paxil
Celexa
Lexapro
Zoloft
53
Q

1st line for PTSD

A

Prozac
Zoloft

Effector

PHARM II FINAL (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions