Antipsychotics Flashcards
1
Q
what happens when you mix clozapine with carbamazepine?
what mix can cause an oculogyric crisis?
what happens when you rapidly dose change antipsychotics?
what combination causes cardiotoxicity?
A
- agranulocytosis
- antipsychotics and metoclopramide
- seizures
- erythromycin and quetiapine
2
Q
why is smoking important in clozapine?
why is it important to do blood tests and how often do you do them?
what GI symptom can clozapine cause?
A
- smoking increases metabolism so smokers require bigger doses
- agranulocytosis: blood testing weekly for 1st 8 weeks, then fortnightly, then monthly
- constipation from bowel impaction (this has been fatal)
