Antipsychotics

Question 1

what are the 5 drugs that have fatal withdrawal symptoms

Answer 1

alcohol

barbituates

Question 2

neuroleptic drugs

Answer 2

not a cure
allow pt to with psychosis to function
MOA: dopamine blockade (block dopamine receptors in brain)
- also work on serotonin receptors

Question 3

typical first generation antipsychotics

Answer 3

phnothiazines

thioxanthenes

Question 4

first generation vs second generation antipsychotics

Answer 4

1st: D2 antagonism
2nd: 5HT2A/D2 antagonism

Question 5

Atypical antipsychotic medications

Answer 5

butyrophenone (typical and atypical)
dibenzodasepine
thienobenzodiasepine
benzisoxazole

Question 6

what is now first line therapy for schizophrenia?

Answer 6

atypical anti-psychotics
- decreased propensity of these agents to cause extrapyramidal effects and absence of prolonged prolactin elevation
affinity for D4 not D2 receptors
- D4 more specific dopamine receptor

Question 7

neuroleptic malignant syndrome

Answer 7

• fluctuating BP, catatonia
• discontinue med
• give tx with dpamine agonist (bromocriptine)

Question 8

chlorpormazine/thorazine

Answer 8

typical neuroleptic
D2 dopaminergic receptor blocker, H1 histimine blockade
psychosis, mania, schizophrenia, n/v, hiccups
se: parkinsonian sx and extrapyramidal signs, increased release of prolactin

Question 9

prochlorperazine/compazine

Answer 9

typical neuroleptic
H1-histamine receptor blocker, D2 blocker
psychosis, vertigo, n/v
se: drowsiness, dry mouth, constipation, urinary retention

Question 10

haloperidol/haldol

Answer 10

typical neuroleptic
D2 receptor blocker
psychosis, tourette’s, huntingtons, agitated behavior
se: excessive sedation, tardive dyskinesia, tremors
*neuroleptic maligna syndrome

Question 11

clozapine/clozaril

Answer 11

atypical neuroleptic
multiple receptor blocker
schizophrenia
se: less extra-pyramidal, *agranulocytosis, myocarditis

Question 12

respiradone/risperdal

Answer 12

atypical neuroleptic
dopamine and serotonin blocker
psychosis
se: weight gain, hyperglycemia, diabetes, stroke, extrapyramidal, constipation, sedation

Question 13

olanzapine

Answer 13

atypical neuroleptic
multiple receptor blocker
schizophrenia
se: weight gain, hyperglycemia, diabetes, stroke, extrapyramidal, constipation, sedation

Question 14

Aripiprazole/abilify

Answer 14

2nd generation atypical anti-psychotic drug, antidepressant, bipolar, schizophrenia
partial dopamine agonist

Question 15

which medications cause weight gain and diabetes

Answer 15

Olanzapine/zyprexa - diabetes, weight gain

Aripirazole?

Question 16

Lithium carbonate/eskalith

Answer 16

Lithium salts
prophylactic to treat bipolar, mania
decreases norepi and increases serotonin
se: renal - decreased response to ADH = impaired concentration, hypothyroidism