Antipsychotics Flashcards

1
Q

Which receptors do first gen antipsychotics block?

A

D2

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2
Q

Which receptors do atypical or second-generation antipsychotics block?

A

Dopamine D2 and Serotonin 2A receptors

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3
Q

Low potency Typical: Thorizine (Chlorpromazine) causes what?

A
  1. orthostatic hypotension, bluish skin discoloration, photosensitivity, can treat intractable hiccups
  2. QT prolongation, heart block, V-Tach
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4
Q

Thioridazine is associated with:

A

retinitis pigmentosa

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5
Q

In acute agitation or psychosis, which neurolwptic would you give>

A

high potency

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6
Q

High potency neuroleptics have greater affinity for dopamine receptors and so a low dose is needed to achieve effect. What are some examples?

A

They cause less sedation, less othostasis, ane less anticholinergic effects

  • but greater risk of EPS and Tardive dyskinesia
  • eg. Haldol, Fluphenazine, Pimozide (Orap)
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7
Q

Which first gen antipsychotics come in injectables?

A

HALDOL, Fluphenazine

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8
Q

Which second gen antipsychotics come in injectables?

A

Risperdone (Consta), Paliperidone (Sustenna)

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9
Q

Where are the positive Sx coming from?

A

mesolimbic dopamine pathway

-includes nucleus accumbens, fornix, amygdala, hippocampus

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10
Q

Where are the negative Sx coming from?

A

mesocortical pathway

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11
Q

EPS is coming from

A

Nigrostriatal pathway

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