Antipsychotics Flashcards
Which receptors do first gen antipsychotics block?
D2
Which receptors do atypical or second-generation antipsychotics block?
Dopamine D2 and Serotonin 2A receptors
Low potency Typical: Thorizine (Chlorpromazine) causes what?
- orthostatic hypotension, bluish skin discoloration, photosensitivity, can treat intractable hiccups
- QT prolongation, heart block, V-Tach
Thioridazine is associated with:
retinitis pigmentosa
In acute agitation or psychosis, which neurolwptic would you give>
high potency
High potency neuroleptics have greater affinity for dopamine receptors and so a low dose is needed to achieve effect. What are some examples?
They cause less sedation, less othostasis, ane less anticholinergic effects
- but greater risk of EPS and Tardive dyskinesia
- eg. Haldol, Fluphenazine, Pimozide (Orap)
Which first gen antipsychotics come in injectables?
HALDOL, Fluphenazine
Which second gen antipsychotics come in injectables?
Risperdone (Consta), Paliperidone (Sustenna)
Where are the positive Sx coming from?
mesolimbic dopamine pathway
-includes nucleus accumbens, fornix, amygdala, hippocampus
Where are the negative Sx coming from?
mesocortical pathway
EPS is coming from
Nigrostriatal pathway