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CNS > Antipsychotics > Flashcards

Antipsychotics Flashcards

0
Q

Prolixin

A

Fluphenazine
1st gen
Phenothiazine
High potency (increased eps)

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1
Q

Thorazine

A

Chlorpromazine
1st gen
Phenothiazine
Low potency (decreased eps)

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2
Q

Haldol

A

Haloperidol
1st gen
Butyrophenone
High potency

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3
Q

Loxitane

A

Loxapine
1st gen
Benzazepine

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4
Q

Trilafon

A

Perphenazine
1st gen
Phenothiazine–> structural derivative of fluphenazine

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5
Q

Mellaril

A

Thioridazine
1st gen
Phenothiazine
Worst for QT prolongation

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6
Q

Stelazine

A

Trifluoperazine

1st gen

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7
Q

Navane

A

Thiothixene
1st gen
Thioxanthene ->sterioisomerism
BBW: dementia related psychosis

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8
Q

Abilify

A 
Aripiprazole
2nd gen
Quinolone derivative
Partial D2 agonist and 5-HT2 antagonist
Dose:10-15mg
2D6,3A4
Maintena inj q month and 2 week overlap
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9
Q

Saphris

A 
Asenapine
2nd gen
Benzazepine 
Dose:10-20mg
Glucuronidation, 1A2
Do not eat or drink for 10 min after SL dose
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10
Q

Clozaril

A 
Clozapine
2nd gen
Benzazepine
Dose:300-450mg
1A2
MACES
Restricted drug 
Metabolic syndrome
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11
Q

Fanapt

A 
Iliperidone
2nd generation
Benzisoxazole
Dose:12-24mg
2D6,3A4
Must trilateral dose up due to dose dependent orthostasis risk. If 3or more days missed re initiate titration
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12
Q

Latuda

A 
Lurasidone
2nd generation
Dose:40-80mg
3A4
5-HT7 ->improved cognitive sxs
Take with a meal >350 calories
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13
Q

Invega

A

Paliperidone (racemic mix of risperidone metabolites)
2nd generation
Benzisoxazole. Active metabolite of risperidone
Dose:3-12mg
Non-CYP
Shell may appear in stool
Invega sustenna inj q month (loading dose) no overlap

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14
Q

Zyrprexa

A 
Olanzapine
2nd gen
Benzazepine
Dose:10-20mg
1A2
Zyrprexa relprevv ing q 2-4 weeks
BBW FOR POST INJECTION Delirium
Worst drug for metabolite syndrome
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15
Q

Seroquel

A 
Quetiapine
2nd gen
Benzazepine
Dose:150-800mg
3A4
Should take XR formulation w/o food or <300 calories
16
Q

Risperidal

A 
Risperidone
2nd gen
Benzisoxazole 
Dose:2-8mg
2D6
Risperidal consta inj q2weeks and overlap for 3 weeks
17
Q

Geodon

A 
Ziprasidone
2nd gen
Benzisothiazole
Dose:40-100mg
3A4
Worst for QT prolongation
Take with food >500 calories

CNS (4 decks)

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