Antipsychotics 1st Generation (Conventional)

Question 1

What are the common antipsychotics 1st generation drugs?

Answer 1

Haloperidol (Haldol)
Fluphenazine 
Loxapine
Thioridazine
Thiothixene (Navane)
Perphenazine
Trifluoperazine

Question 2

What are the expected pharmacological action?

Answer 2

-Block dopamine (D2), acetylcholine, histamine, and norepinephrine receptors in the brain.

Question 3

Therapeutic uses?

Answer 3

Schizophrenia
Bipolar disorder
Tourette’s disorder
Treatment of acute and chronic psychotic disorders

Question 4

Common adverse effects?

Answer 4

• Agranulocytosis (Check WBCs)
• Anticholinergic effects
• Parkonsonism
• Neuroleptic malignant syndrome
• Orthostatic hypotension
• Severe Dysrhythmias

Question 5

Common contraindications and precautions?

Answer 5

• Coma
• Severe depression
• Parkinson’s disease
• Severe hypotension
• Dementia
• Heart, liver, kidney disorders
• Breast cancer