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Pharmacology Drugs > Antipsychotics > Flashcards

Antipsychotics Flashcards

1
Q

Chlorpromazine

A

Antipsychotic
1st generation
DA block
Aliphatic extension
Antipsychotic and antimuscarinic

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2
Q

Haloperidol

A

Antipsychotic
1st generation
High potency on D2

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3
Q

Thioridazine

A

Antipsychotic
Piperidine side chain
Middle potency
Middle sedation

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4
Q

Fluphenazine

A

Antipsychotic
Piperazine side chain
Most potent
Least sedative

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5
Q

Sulpiride

A

Antipsychotic
Benzamide
Potent D2 blocker
Less off-target effects
Less risk of EPS (targets mesolimbic over negrostriatal)
Good antipsychotic properties

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6
Q

Dantrolene

A

Muscle relaxant

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7
Q

Clozapine

A

Antipsychotic
Atypical
Effective
Active metabolite
Agranulocytosis
High risk of weight gain

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8
Q

Olanzapine

A

Antipsychotic
Clozapine derived
No agranulocytosis
Atypical
Good serotonin affinity

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9
Q

Apriprazole

A

Antipsychotic
Atypical
PARTIAL agonist (agonist in low DA, antagonist in high DA)
High affinity for 5-HT2A receptor
Low EPS
Does not increase prolactin
Also an antidepressant

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Pharmacology Drugs (5 decks)

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