Antipsychotic Side-effects

Question 1

Extrapyramidal

Least likey

Answer 1

COQA

• Clozapine
• Olanzapine
• Quetiapine
• Arapiprazole

Question 2

Hyperprolactaemia

Most + Least likely

Answer 2

Most (RAFS)

• Risperidone
• Amisulpride
• First gen
• Sulpride

Least (AACCQ)
- arapiprazole
- Asencecepine
- Clozapine
- Cariprazine
- Quetipaine

Question 3

Sexual Dysfunction

Most + Least likely

Answer 3

Most (ROH)
- risperidone
- olanzapine
- haloperidol

Least (QA)
- Quetiapine
- Arapiprazole

Question 4

CV + QT

Most + least

Answer 4

Most: haloperidol + primidone
Least: arapiprazole

Question 5

Hypotension

Most

Answer 5

Most likely:
- Clozapine
- Quetiapine

Question 6

Diabetes

Most

Answer 6

Most:
- Clozapine
- Quetiapne
- Risperidone
- Olanzapine

Question 7

Weight gain

Most + least

Answer 7

Most: olanzapine + clozapine
Least: arapiprazole + haloperidol + amisulprode

Question 8

Monitoring

Answer 8

Weight:-
- before
- weekly for 6 weeks
- at 12 weeks
- at 1 year
- yearly

FBC, glucose, Hba1C, lipids
- before
- 12 weeks
- 1 year

Prolactin
- baseline

FBC + U&Es + LFTs
- baseline
- yearly

BP
- before
- 12 week
- yearly

(more monitoring required for clozapine)

Question 9

Which antipsychotics affected by smoking

Answer 9

• clozapine
• haloperidol
• olanzapine
• chlorpromazine

Metabolism drug increased