Anti-epileptic Interactions

Question 1

What anti-epileptics are enzyme inducers?

Answer 1

Enzyme-inducing antiepileptic drugs include:
* Carbamazepine.
* Eslicarbazepine acetate.
* Oxcarbazepine.
* Perampanel (at a dose of 12 mg daily or more).
* Phenobarbital.
* Phenytoin.
* Primidone.
* Rufinamide.
* Topiramate (at a dose of 200 mg daily or more)

Question 2

Which anti-epileptics can cause acute psychotic reactions

Answer 2

Acute psychotic reactions — seen occasionally with vigabatrin, topiramate and tiagabine, particularly if there is a previous history of psychiatric disease. Recovery usually occurs on withdrawal from the drug

Question 3

Which anti-epileptic is an autoinducer?

Answer 3

Carbamazepine

is also an autoinducer, meaning that its half-life can decrease after prolonged therapy.

Question 4

Which anti-epileptic is an autoinducer?

Answer 4

Carbamazepine

is also an autoinducer, meaning that its half-life can decrease after prolonged therapy.

Question 5

Carbamazepine + MAOIs

Answer 5

Avoid co-comitant use + Carb use within 2 weeks of discontinuing MAOI

Question 6

Carbamazepine + macrolides

Answer 6

Increased risk of carb toxicity