Antipsychotic drugs to treat schizophrenia

Question 1

What was the first drug

Answer 1

Chlorpromazine

Question 2

What are the 2 types of anti psychotics

Answer 2

• Typical (chlorpromazine)

- Atypical (chlozapine)

Question 3

key facts about Typical

Answer 3

• Developed in 1950’s
• Agonist of Dopamine receptors D1,2,3,4,5
• Reduction in dopamine activity in mesolimbic pathway causes a reduction in positive symptoms

Question 4

key facts about Atypical

Answer 4

• Developed in 1990’s
• Agonist of D1,2 and 4 receptor sites
• Greater effect on serotonine receptors than typical
• Fewer side effects than typical
• ## Half life is short than typical