Antiprotozoals

Question 1

Chloroquine

Answer 1

Anti malarial 4-aminoquinolone drug
Accumulates in food vacuoles where haemoglobin is used as a source of protein
Haem biproduct may form ROS so is dimerised to hemozin
Chloroquine inhibits this

Question 2

Sulfadoxine

Answer 2

Anti malarial Sulfa drug- sulfaoxazole equivalent

P-aminobenzoate analogue - inhibits DHPS in folic acid pathway

Question 3

Pyrimethamine

Answer 3

Antimalarial trimethoprim equivalent

Inhibits DHFR

Question 4

Fansidar

Answer 4

Antimalarial co-trimoxazole equivalent
Combination of Sulfadoxine and pyrimethamine
Used to treat p. Falciparum

Question 5

Arteminsin

Answer 5

Anti malarial prodrug of dihydroarteminsin
Acts on Protozoa in erthyrocytes, producing ROS by unknown mechanisms
Also prevent oocyst formation in mosquitos

Question 6

Suramin

Answer 6

Choice anti-trypanosome drug (lower therapeutic index than melarsen)
Inhibits glycolytic enzymes
Glycerol 3P oxidase and NAD+ dependent glycerol 3P dehydrogenase
This prevents ATP synthesis