Antiplatelets Flashcards

1
Q

Action

A

Stop initial platelet plug

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2
Q

What are the names of some common antiplatelets?

A

Clopidgrel (Plavix)
Dipyridamole/aspirin (Aggrenox)
Aspirin
Cilostazol (Pletal)

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3
Q

For whom are antiplatelets preferred?

A

Patients with non-cardioembolic stroke

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4
Q

What is the indication for Clopidogrel (Plavix)?

A

Secondary prevention after a thrombotic stroke

Patients unable to take Warfarin after a cardioembolic stroke

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5
Q

Side effects - Clopidogrel (Plavix):

A

Bleeding
Bruising
Rash
Itching

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6
Q

Drug interactions - Clopidogrel (Plavix):

A
Omeprazole
Lansoprazole
Dexlansoprazole
Esomprazole
*other anticoagulants*
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7
Q

What is are indications for Dipyridamole/aspirin (Aggrenox)?

A

Secondary prevention after a thrombotic stroke

Patients who are unable to take Warfarin after a cardioembolic stroke

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8
Q

What is Dipyridamole/aspirin (Aggrenox)?

A

Timed-release –> combined c aspirin

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9
Q

Side effects - Dipyridamole/aspirin (Aggrenox):

A
Bleeding
Bruising
Headache
Abdominal pain
Diarrhea
Heartburn
Nausea
Tinnitus
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10
Q

Drug interactions - Dipyridamole/aspirin (Aggrenox):

A

Colchicine
Keterolac
Live influenza and varicella vaccines
Anticoagulants

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11
Q

Contraindications - Dipyridamole/aspirin (Aggrenox):

A
Asthma
Rhinitis
Nasal polyps
NSAID allergy
3rd trimester of pregnancy
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12
Q

Clinical considerations - Dipyridamole/aspirin (Aggrenox):

A

Alcohol consumption may increase GI irritation and bleeding risk

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13
Q

Indication for aspirin:

A

Started w/in 48hrs of CVA

May be used as monotherapy after a first-time thrombotic stroke

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14
Q

Aspirin - side effects:

A
GI bleeding
Anemia
Ringing in the ears (tinnitus)
Aspirin allergy
Acute toxicity
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15
Q

Aspirin - contraindications:

A

Asthma
Rhinitis
Nasal polyps
Bleeding disorders

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16
Q

Aspirin - clinical considerations:

A

DO NOT USE W/IN 24 HOURS OF ALTEPLASE

AVOID IN SEVERE RENAL OF HEPATIC IMPAIRMENT

17
Q

Are baby aspirins okay to take prior to surgery?

A

Yes

18
Q

When should anti-inflammatories be stopped prior to surgery?

A

48 hours before to prevent abnormal bleeding

19
Q

When should aspirin be stopped prior to surgery and why?

A

7-10 days prior –> it permanently stops the platelets from forming clots, so need to wait for new platelets to form

20
Q

What is the half-life for anti-inflammatories that needs to be taken into consideration (i.e. Stopping taking 48 hours prior to surgery)?

A

5 1/2 half lives