Antiplatelets

Question 1

Heparin MOA

Answer 1

Binds Antithrombin III –> inactivates IIa and Xa

rapid onset

Question 2

Heparin Adverse Effects

Answer 2

Bleeding and thrombocytopenia

Question 3

Low-Moleclar Weight Heparin MOA

Answer 3

binds ATIII –> inactivates Xa

onset 3-5 hours

Question 4

Protamine

Answer 4

antidote for LMWH and Heparin OD

Question 5

Low-Molecular Weight Heparin Adverse Effects

Answer 5

Bleeding and thrombocytopenia

Question 6

Warfarin MOA

Answer 6

Inhibits liver synthesis of vitamin K dependant factors (II, VII, IX and X)

Delayed onset (hours to days)

Question 7

Warfarin monitoring

Answer 7

INR (from PT)

NOT safe in pregnancy

Question 8

Warfarin Adverse Reactions

Answer 8

Bleeding, skin necrosis

Question 9

Aspirin MOA

Answer 9

low dose - “selective” inhibition of platelet COX-1

can be rapid onset

Question 10

Aspirin Uses

Answer 10

Acute MI
Unstable angina (ACS)
PCI

Question 11

Aspirin Adverse effects

Answer 11

gastric upset

bleeding

Question 12

Heparin Uses

Answer 12

acute coronary syndrome

Question 13

Warfarin Uses

Answer 13

A-fib