Antiplatelets

Question 1

Aspirin MOA?

Answer 1

M.O.A: irreversibly inhibits platelet COX-1 → ↓ thromboxane formation → no platelet aggregation

Question 2

Uses of Aspirin?

Answer 2

Reduce the risk of heart attacks and strokes

Question 3

Adverse effects of Aspirin?

Answer 3

1. Bleeding
2. Bronchospasm

Question 4

Which anti-platelet drug is more potent than aspirin but causes less bleeding?

Answer 4

Clopidogrel

Question 5

Clopidogrel MOA?

Answer 5

M.O.A: irreversibly inhibit ADP receptors (P2Y12 receptors) → no platelet aggregation

Question 6

Uses of Clopidogrel?

Answer 6

Reduce the risk for heart attacks and stroke

Question 7

Adverse effect of Clopidogrel?

Answer 7

Bleeding disorders

Question 8

Uses of Abciximab (2) ?

Answer 8

1- unstable angina
2- following percutaneous coronary intervention

Question 9

Which antiplatelet drug causes a 48 hour platelet dysfunction?

Answer 9

Abciximab

Question 10

Abciximab MOA?

Answer 10

M.O.A: An antibody that blocks platelet glycoprotein IIb/IIIa receptors

Question 11

Which antiplatelet drug has a short half life due to strong, fast, and prolonged binding of the drug to the receptor?

Answer 11

Abciximab

Question 12

Which antiplatelet drugs reduce the risk of heart attacks and strokes?

Answer 12

Aspirin & Clopidogrel