Antiplatelets Flashcards
1
Q
What is involved in primary haemostasis
A
unstable platelet plug formation through platelet adhesion and aggregation to limit blood loss
2
Q
What is involved in secondary haemostasis
A
coagulation cascade
3
Q
How do platelets originate
A
from megakaryocytes in the bone marrow which differentiate from hematopoietic stem cells
Megakaryocytes lose their ability duplicate DNA by mitosis and this leads to a polyploid megakaryocyte
the cytoplasm matures and becomes granular which forms a platelet
4
Q
Where are platelets stored
A
the spleen
5
Q
Name 5 types of antiplatelet agents
A
- Aspirin
- PAR1 inhibitors
- P2Y12 antagonists
- αIIbβ3 antagonists
