AntiPhospholipid Syndrome Flashcards
clinical manifestations of APS
recurrent arterial or venous thrombotic disease and/or recurrent fetal loss
patho of APS
autoantibody production against cell membrane phosopholipids
types of APS
- primary APS
2. secondary APS (APS + rheumatic dz)
mc associated rheumatic dz in APS
SLE
other commonly associated diseases with APS
Sjogren’s and RA
diagnosis of APS req/
one clinical (thrombosis or pregnancy) and one laboratory criteria
APS associated clinical features
cardiac valve dz lived reticularis nephropathy thrombocytopenia neuro manifestations
vascular thrombosis criteria
one or more clinical episodes of arterial, venous, or small vessel thrombosis
pregnancy morbidity
miscarriage
one or more late term (>10 weeks gestation) OR 3 or more unexplained consecutive early (<10 weeks) spontaneous abortions
pregnancy morbidity
placenta
premature birth of morphologically healthy neonate at or before 34 weeks bc of severe preeclampsia, eclampsia, severe placental insufficiency
laboratory criteria
anti-cardiolipin antibodies
anti-beta 2 glycoprotein I antibodies
lupus anti-coaglulant
when to suspect APS
thrombotic disease (micro and macro) 0 young pts w/o risk factors or recurrent
hematologic dz
cutaneous manifestations
neuro dz
what might cause second hit of APS
virchow’s triad
therapeutics of APS
eliminate other risk factors (estrogen, smoking, HTN, hyperlipidemia)
Low dose aspirin
hydroxychloroquinine
if thrombosis occurs management:
LMWH or UF Heparin
tailor lifelong with patient
target INR 2-3 (If warfarin)
