Antiparkinsons

Question 1

Rasagiline (Azilect)

Answer 1

A Selective MAO-B Inhibitor

Breaks down Catecholamines

Increases dopaminergic stimulation in CNS

Loses Selectivity at higher doses

Monotherapy or in conjunction with Levodopa therapy

Question 2

Selegiline (Eldepryl)

Answer 2

SAME AS Rasagiline

“A Selective MAO-B Inhibitor

Breaks down Catecholamines

Increases dopaminergic stimulation in CNS

Loses Selectivity at higher doses

Monotherapy or in conjunction with Levodopa therapy”

Question 3

Bromocriptine

Answer 3

Stimulates D2 receptors and Antagonizes D1 receptors

Delays need for Levodopa

May be given with Carbidopa-Levodopa

Can worsen Vascular Disease

Dyskinesias

Question 4

Pramipexole (Mirapex)

Answer 4

Non-ergot NDDRA (non dopamine dopamine receptor agonist)

Used to treat: Early and late stage Parkinson’s

Delays need for Levodopa

Fewer Dyskinesias than Bromocriptine

Question 5

Entacapone (Comtan)

Answer 5

COMT Inhibitor Catechol-O-methyltransferase inhibitors)

Adjunctive therapy with Levodopa

Reduces on-off effects

Caution in pre-existing liver disease

Question 6

Amantadine

Answer 6

Antiviral Drug

Used to treat: Mild to Moderate Parkinson’s

Dopaminergic and Anticholinergic Effects

Question 7

Carbidopa-Levodopa (Sinemet)

Answer 7

Dopamine Agonist

Directly Replaces Dopamine

Carbidopa decreases the Adverse Effects of Levodopa

GI Side Effects

Take on an empty stomach*

Question 8

Benztropine Mesylate (Cogentin)

Answer 8

Used to treat: Parkinsons and Extrapyramidal symptoms from antipsychotics

May cause HYPERTHERMIA

Anticholinergic symptoms

Anticholinergic Syndrome