Antineoplastics Flashcards
Alemtuzumab MOA Indication SE's DI Comments
MOA - Anti CD52 MAB
Indication - CLL
SE’s - Immunosuppression, neutropenia, infusion related reactions
DI - Vaccines and immunosuppressants
Comments - interactions are not enzyme mediated
Arsenic Trioxide MOA Indication SE's DI Comments
MOA - Differentiating agent Indication - APL SE's - Differentiation syndrome, neuropathies DI - QT prolonging medications Comments - NA
Azacitidine MOA Indication SE's DI Comments
MOA - Hypomethylating agent Indication - AML, MDS SE's - Myelosuppression, nausea DI - Immune suppressants, echinacea Comments - Delayed onset of effect (2-4 cycles)
Belinostat MOA Indication SE's DI Comments
MOA - Histone deacetylase inhibitor Indication - Peripheral T-cell lymphoma SE's - Myelosuppression, nausea, fatigue DI -UGT1A1 and PGP inhibitors or inducers Comments - NA
Bendamustine MOA Indication SE's DI Comments
MOA - Alkylating agent Indication - CLL, NHL SE's - Myelosuppression, nausea, emesis DI - CYP 1A2 inhibitors Comments - N/A
Bleomycin MOA Indication SE's DI Comments
MOA - inhibits DNA and RNA synthesis Indication - HD, NHL SE's - Pulmonary toxicity, hyper pigmentation, Raynauds DI - Brentuximab vaccines Comments - Lifetime max dose 400 units
Blinatumomab MOA Indication SE's DI Comments
MOA - anti CD 19 MAB that links to cytotoxic T-cells
Indication - ALL
SE’s - Cytokine release syndrome, tumor lysis, leukoencephalopathy
DI - vaccines
Comments - murine antibody
Bortezomib MOA Indication SE's DI Comments
MOA - Proteasome inhibitor
Indication - Myeloma, NHL
SE’s - Neuropathy, diarrhea, thrombocytopenia
DI - CYP 3A4 inducers, green tea, CYP 2C19 substrates
Comments - SQ administration decreases neuropathy
Brentuximab vedotin MOA Indication SE's DI Comments
MOA - Anti-CD 30 MAB linked to microtubule inhibitor
Indication - HD
SE’s - Rach, neuropathy, myelosuppression
DI - Bleomycin, CYP 3A4 inhibitors or inducers
Comments - Dosing maxed at 100kg (dosed per kg)
Busulfan MOA Indication SE's DI Comments
MOA - Alkylating agent
Indication - CML, used for BMT
SE’s - Myelosuppression, hyperpigementation, n/v, lowers seizure threshold, veto-occlusive disease
DI - APAP, avoid CYP inhibitors and inducers
Comments - Prophylactic anticonvulsants used with BMT
Carboplatin MOA Indication SE's DI Comments
MOA - Platinum alkylating agent Indication - HD, NHL SE's - N/V, myelosuppression, neuropathy DI - Mesna, immune suppressants Comments - Dosed per GFR based on Calvert formula
Carfilzomib MOA Indication SE's DI Comments
MOA - Proteasome inhibitor Indication - myeloma SE's - heart failure, fatigue, nausea DI - PGP/BCRP inhibitors Comments - Dosed at maximum BSA 2.2m squared
Carmustine MOA Indication SE's DI Comments
MOA - Alkylating agent
Indication - HD, NHL
SE’s - Myelosuppression, pulmonary fibrosis, n/v
DI - immunosuppressants, vaccines
Comments - dissolved in dehydrated alcohol
Chlorambucil MOA Indication SE's DI Comments
MOA - Alkylating agent Indication - CLL SE's - myelosuppression, mucositis DI - Other myelosuppressive agents Comments - Take on empty stomach
Cisplatin MOA Indication SE's DI Comments
MOA - Platinum alkylating agent Indication - NHL, HD SE's - N/v, nephrotoxic, neuropathies DI - Concomitant nephrotoxins Comments - delayed nausea common
Cladribine MOA Indication SE's DI Comments
MOA - purine analog Indication - CLL, NHL, hairy cell leukemia SE's - infections, myelosuppression DI - live vaccines Comments - Needs PJP prophylaxis
Clofarabine MOA Indication SE's DI Comments
MOA - Purine analog Indication - ALL< AML SE's - Infections, myelosuppression, capillary leak syndrome DI - Live vaccines Comments - needs PJP prophylaxis
Cyclophosphamide MOA Indication SE's DI Comments
MOA - Alkylating agents
Indication - ALL, NHL, myeloma
SE’s - hemorrhagic cystitis, myelosuppression, SIADH
DI - CYP 2B6 inhibitors, CYP inducers
Comments - Mesna may be used as a bladder protectant
Cytarabine MOA Indication SE's DI Comments
MOA - Pyrimidine analogue
Indication - AML, NHL, HD
SE’s - Myelosuppression (high dose - conjunctivitis, cerebellar toxicity), acral erythema
DI - Concomitant immune suppressants
Comments - Steroid eye drops used with high dose
Dacarbazine MOA Indication SE's DI Comments
MOA - Alkylating agent
Indication - HD
SE’s - myeosuppression, n/v, photosensitivity
DI - CYP 1A2 oe 2E1 inhibitors or inducers
Comments - N/A
Daratumumab MOA Indication SE's DI Comments
MOA - AntiCD 38 MAB
Indication - myeloma
SE’s - infusion reactions, myelosuppression
DI - none
Comments - interferes with RBC cross-matching
Dasatinib MOA Indication SE's DI Comments
MOA - Inhibits BCR-ABL kinase Indication - CML, Ph+ALL SE's - Fluid retention, rash, myelosuppression, pleural effusion DI - CYP 3A4 inhibitors, acid reducers Comments - Taken w/o regards to food
Daunorubicin MOA Indication SE's DI Comments
MOA - DNA intercalator, free radical generation, topoisomerase II inhibitor
Indication- AML, ALL
SE’s - Vesicant, HF, arrhythmias, skin flare, urine discoloration, myelosuppression
DI - Avoid PGP and ABCB1 inducers or inhibitors
Comments - Lifetimes maximum of 500 mg/m squared suggested
Decitabine MOA Indication SE's DI Comments
MOA - Hypomethylating agent Indication - AML, MDS SE's - Myelosuppression, edema, nausea DI - N/A Comments - May take several cycles for full effect
Doxorubicin MOA Indication SE's DI Comments
MOA- DNA intercalator, free radical generation, topoisomerase II inhibitor
Indication - NHL, HD, myeloma
SE’s - Vesicant, HF, arrhythmias, skin flare, urine discoloration, myelosuppression
DI - Avoid CYO 3A4 and PGP inhibitors or inducers
Comments - Lifetime maximum of 550 mg/m squared suggested
Dexamethasone MOA Indication SE's DI Comments
MOA - Lympholytic corticosteroid
Indication - CLL, ALL, NHL, HD, myeloma
SE’s - Hyperglycemia, osteoporosis, mood changes, cataracts
DI - Inhibits multiple CYP enzymes so be aware of other substrates with narrow therapeutic margins
Comments - Take with food, infuse large doses slowly
Doxorubicin, Liposomal MOA Indication SE's DI Comments
MOA - DNA intercalator, free radical generation, topoisomerase II inhibitor
Indication - myeloma
SE’s - hand foot syndrome, arrhythmia, HF, myelosuppression, infusion reactions
DI - avoid CYP 3A4 inhibitors or inducers
Comments - lifetime max of 550 mg/m2 suggested
Elotuzumab MOA Indication SE's DI Comments
MOA - Anti SLAMF-7 MAB Indication - Myeloma SE's - N/A DI - M/A Comments - Premedicate with H1 and H2 blocker and APAP
Etoposide MOA Indication SE's DI Comments
MOA - Topoisomerase II inhibitor
Indication - NHL, AML, HD
SE’s - Myelosuppression, hypotension, nausea, stomatitis
DI - Avoid CYP 3A4 inhibitors and inducers
Comments - Infuse over 1 hour minimum
Fludarabine MOA Indication SE's DI Comments
MOA - Purine analog Indication - AML, CLL, NHL SE's - myelosuppression, encephalopathy, infections DI - Live vaccines Comments - Needs PJP prophylaxis
Gemtuzumab MOA Indication SE's DI Comments
MOA - Anti CD 33 MAB linked to an alkylating agent
Indication - AML
SE’s - Myelosuppression, veni-occlusive disease
DI - N/A
Comments - Light sensitive compound
Hydroxyurea MOA Indication SE's DI Comments
MOA - Ribonucleotide reductase inhibitor Indication - AML, ALL, CML SE's - Myelosuppression, cutaneous ulcers, hyperuricemia DI - N/A Comments - Take without regards to food
Ibritumoman Y-90 MOA Indication SE's DI Comments
MOA- Anti CD 20MAB linked to I-131
Indication - NHI
SE’s - myelosuppression, infusion reactions
DI - N/A
Comments - Pre-dose targeting done to estimate location and extent of radiation and exposure, murine antibody
Ibrutinib MOA Indication SE's DI Comments
MOA - Bruton’s tyrosine kinase inhibitor
Indication
- CLL, NHL
SE’s - hemorrhage, myelosuppression, infections, rash
DI - Avoid CYP 3A4 inducers and strong 3A4 inhibitors
Comments - Take on empty stomach
Idelalisib MOA Indication SE's DI Comments
MOA - PI-3 kinase inhibitor
Indication - CLL
SE’s - Cutaneous reaction, increased glucose and triglycerides
DI - Avoid CYP inducers, strong 3A4 inhibitors
Comments - Take with food
Idarubicin MOA Indication SE's DI Comments
MOA - DNA intercalator, free radical generation, topoisomerase II inhibitor
Indication- AML
SE’s - Myelosuppression, vesicant, colors urine red, radical arrhythmias and HF
DI - Avoid PGP/ABCB1 inhibitors and inducers
Comments - Maximum lifetimes dose of 150mg/m2
Ifosfamide MOA Indication SE's DI Comments
MOA - Alkylating agent
Indication - NHL, HD
SE’s - Myelosuppression, encephalopathy, hemorrhagic cystitis, n/v
DI - Avoid Cap 2A6, 2C19, and 3A4 inhibitors and inducers
Comments - use with Mesna
Imatinib Mesylate (Gleevec) MOA Indication SE's DI Comments
MOA - BCR-ABL kinase inhibitor Indication - CML, Ph+ALL SE's - Edema , nausea, rash, myelosuppression DI - Inhibits CYP 3A4 Comments - Take with food
Interferon (Intron A) MOA Indication SE's DI Comments
MOA - Immune Modulator
Indication - CML, NHL
SE’s - Flulike symptoms, depression, anorexia, myelosuppression
DI - N/A
Comments - May aggravate autoimmune disorders
Ixazomib (Ninlaro) MOA Indication SE's DI Comments
MOA - Proteasome inhibitor Indication - myeloma SE's - peripheral neuropathy, diarrhea, thrombocytopenia, edema DI - Avoid strong CYP 3A4 inducers Comments - Take on an empty stomach
L-asparaginase (Erwinaze) MOA Indication SE's DI Comments
MOA - Enzyme vs asparagine
Indication - ALL
SE’s - Hypersensitivity reactions, pancreatitis, thrombosis, bleeding
DI - Methotrexate, prednisone, vincristine
Comments - Give after vincristine
Lenalidomide (Revlimid) MOA Indication SE's DI Comments
MOA - Immune modulating agent
Indication - MDS, myeloma, NHL
SE’s - Thrombosis, myelosuppression, secondary leukemia
DI - PGP inhibitors
Comments - Teratogenic, take without regard to food
Lomustine (CeeNU) MOA Indication SE's DI Comments
MOA - Alkylating agent Indication- HD SE's - Melosuppression, CNS side effects, N/V DI - N/A Comments - Take on an empty stomach
Meclorethamine (mustargen) MOA Indication SE's DI Comments
MOA - Alkylating agent Indication - HD SE's - Myelosuppression, n/v DI - N/A Comments - N/A
Melphalan (Alkeran) MOA Indication SE's DI Comments
MOA - Alkylating agent Indication - Myeloma SE's - myelosuppression, rash, mucositis DI - N/A Comments - Use cryotherapy in mouth during high dose infusions, oral taken on empty stomach
Mercaptopurine (Purinethol) MOA Indication SE's DI Comments
MOA - Purine analog Indication - ALL SE's - Myelosuppression, diarrhea, mucositis DI - Allopurinol Comments - Take on an empty stomach
Methotrexate (Trexal) MOA Indication SE's DI Comments
MOA - Dihydrofolate reductase inhibitor
Indication - NHL, ALL
SE’s - Myelosuppression, mucositis, nephrotoxic
DI - PCN, NSAIDs, PPI, quinolones
Comments - Need to alkalinize urine when administering high dose
Methylprednisone (Medrol) MOA Indication SE's DI Comments
MOA - Lympholytic corticosteroid
Indication - CLL, ALL, NHL, HD, myeloma
SE’s - Hyperglycemia, osteoporosis, mood changes, cataracts
DI - inhibits multiple CYP enzymes so be aware of other substrates with narrow therapeutic margins
Comments - Take with food, infuse large doses slowly
Mitoxantrone (Novantrone) MOA Indication SE's DI Comments
MOA - DNA intercalator, free radical generation, topoisomerase II inhibitor
Indication - AML, NHL
SE’s - Myelosuppression, vesicant, cardiotoxic (HF, arrythmias), colors urine blue-green
DI - N/A
Comments - Lifetime max dose 160 mg/m2
Nelabarine (Arranon) MOA Indication SE's DI Comments
MOA - Purine analog Indication - T-ALL and NHL SE's - Myelosuppression, neurotoxicity DI - Live vaccines Comments - Requires PJP prophylaxis
Nilotinib (Tasigna) MOA Indication SE's DI Comments
MOA - BCR-ABL kinase inhibitor
Indication - CML, Ph+ALL
SE’s - Myelosuppression, QTc prolongation, pancreatitis
DI - Avoid CYP 3A4 inhibitors and inducers. It is a moderate inhibitor of 2D6, 2C8/9 so avoid substrates with narrow margins
Comments - Take on empty stomach
Nivolumab (Opdivo) MOA Indication SE's DI Comments
MOA - Anti PD-1 MAB Indication - HD SE's - Autoimmune conditions DI - N/A Comments - N/A
Obinatuzumab (Gazyva) MOA Indication SE's DI Comments
MOA - Anti CD 20 MAB
Indication - CLL, NHL
SE’s - Infusion reactions, Hep B reactivation, PML, tumor lysis syndrome
DI- N/A
Comments - Concider holding anti-hypertensives the day of infusion
Ofatumumab (Arzerra) MOA Indication SE's DI Comments
MOA - Anti CD 20 MAB
Indication - CLL
SE’s - Infusion reactions, Hep B reactivation, PML, tumor lysis syndrome
DI - N/A
Comments - Consider holding antihypertensives the day of infusion
Omacetaxine (Synribo) MOA Indication SE's DI Comments
MOA - protein synthesis inhibitor
Indication - CML
SE’s - Myelosuppression, diarrhea, fatigue
DI - N/A
Comments - Delayed time to response but affects many mutated BCR-ABL forms
Oxaliplatin (Eloxatin) MOA Indication SE's DI Comments
MOA - Platinum alkylating agent Indication - NHL SE's - myelosuppression, n/v, neuropathy DI - N/A Comments - Do not touch or consume cold items for 72 hours postdose
Pabobinostat (Farydak) MOA Indication SE's DI Comments
MOA - Histone deacetylase inhibitor Indication - Myeloma SE's - diarrhea, fatigue, nausea DI - N/A Comments - N/A
Pegasparaginase (Oncaspar) MOA Indication SE's DI Comments
MOA - Enzyme vs asparagine
Indication - ALL
SE’s - Hypersensitivity reactions, pancreatitis, thrombosis, bleeding
DI - Methotrexate, prednisone
Comments - Less antigenic than other asparaginase forms
Pentostatin (Nipent) MOA Indication SE's DI Comments
MOA - Purine analogue Indication - CLL, NHL SE's - myelosuppression, neurologic changes, infections DI - live vaccines Comments - need PJP prophylaxis
Pomalidomide (Pomalyst) MOA Indication SE's DI Comments
MOA - Immune modulating agent
Indication - Myeloma
SE’s - Myelosuppression, thrombogenic, neuropathy, secondary AML
DI - Avoid 1A2 and 3A4 inhibitors and inducers
Comments - teratogenic
Ponatinib (Iclusig) MOA Indication SE's DI Comments
MOA - BCR-ABL kinase inhibitor
Indication - CML
SE’s - hypertension, thrombosis, hepatic abnormalities, pancreatitis, HF
DI - Avoid use with strong 3A4 inhibitors or inducers
Comments - Take without regard to food
Pralatrexate (Folotyn) MOA Indication SE's DI Comments
MOA - Dihydrofolate reductase inhibitor
Indication - NHL
SE’s - Myelosuppression, mucostis, nausea
DI - Uricosurics, nephrotoxins, sulfa drugs
Comments - Take B-12 and folate supplementation
Prednisone (Deltasone) MOA Indication SE's DI Comments
MOA - Lymptholytic corticosteroid
Indication - CLL, ALL, NHL, HD, myeloma
SE’s -hyperglycemia, osteoporosis, mood changes, cataracts
DI - Inhibits multiple CYP enzymes so be aware of other substrates with narrow therapeutic margins
Comments - Take with food, infuse large doses slowly
Procarbazine (Matulane) MOA Indication SE's DI Comments
MOA - Alkylating agent
Indication - NHL, HD
SE’s - myelosuppression, n/v, neurotoxicity
DI - Amphetamines, meperidine, SSRI, tricyclics, ethanol
Comments -Avoid fermented beverages and foods (MAOI)
Rituximab (Rituxan) MOA Indication SE's DI Comments
MOA - Anti CD 20 MAB
Indication - NHL, CLL, ALL
SE’s - Infusion reactions, Hep B reactivation, PML, tumor lysis syndrome
DI - N/A
Comments - Consider holding antihypertensives the day of infusion
Romidepsin (Istodax) MOA Indication SE's DI Comments
MOA - Histone deacetylase inhibitor Indication - NHL SE's - fatigue, fever, n/v, myelosuppression DI - avoid CYP inhibitors and inducers Comments - N/A
Ruxolitinib (Jakafi) MOA Indication SE's DI Comments
MOA - Jak 1 and 2 kinase inhibitor
Indication - myelofibrosis, polycythemia vera
SE’s - myelosuppression, peripheral edema, diarrhea, hepatic abnormalities
DI - Avoid CYP inhibitors and inducers
Comments - Rebound effect after stopping. Take without regard to food.
Temozolomide (Teomdar) MOA Indication SE's DI Comments
MOA - Alkylating agent Indication - NHL SE's - Myelosuppression, n/v, rash DI - N/A Comments - Administer consistently with regard to food, empty stomach preferred
Teniposide (Vumon) MOA Indication SE's DI Comments
MOA - Topoisomerase II inhibitor Indication - Pediatric leukemias SE's - myelosuppression, n/v, mucositis DI - phenytoin, carbamazepine, phenobarbital Comments - N/A
Thalidomide (Thalomid) MOA Indication SE's DI Comments
MOA - Immune modulating agent
Indication - MDS, myeloma
SE’s - Sedation, neuropathy, constipation, thrombogenic
DI - N/A
Comments - Teratogenic, take on an empty stomach
Thioguanin (Tabloid) MOA Indication SE's DI Comments
MOA - purine analogue Indication - ALL SE's - myelosuppression, diarrhea, mucositis DI - N/A Comments - Take without regard to food
Thiotepa (Tepadina) MOA Indication SE's DI Comments
MOA - Alkylating agent
Indication - NHL, HD
SE’s - myelosuppression, skin toxicity, mucositis
DI - N/A
Comments - Cower several times a day during high dose as secreted in sweat
Topotecan (Hycamtin) MOA Indication SE's DI Comments
MOA - Topoisomerase I inhibitor Indication - NHL, HD SE's - Myelosuppression, mucositis, n/v DI - phenytoin, cisplatin Comments - Give before cisplatin
Tositumomab I-131 (Bexxar) MOA Indication SE's DI Comments
MOA - Anti CD 20 MAB linked to Y-90
Indication - NHL
SE’s -myelosuppression, infusion reactions
DI - N/A
Comments - Pre-dose targeting done to estimate location and extent of radiation exposure, murine antibody thyroid protective agent given prior to dose
Tretinoin (Vesanoid) MOA Indication SE's DI Comments
MOA - Differentiating agent
Indication - APL
SE’s - Hepatotoxic, headaches, skin changes
DI - Avoid CYP 2C8 inhibitors and inducers
Comments - Take with food
Venetoclax (Venclextra) MOA Indication SE's DI Comments
MOA - N/A Indication - CLL SE's - N/A DI - N/A Comments - N/A
Vinblastine (Velban) MOA Indication SE's DI Comments
MOA - Inhibits microtubule formation Indication - HD SE's - myelosuppression, neuropathy DI - Avoid CYP 3A4 inhibitors or inducers Comments - Fatal if given intrathecally
Vincristine (Oncovin) MOA Indication SE's DI Comments
MOA - Inhibits microtubule formation Indication - ALL, NHL, HD, myeloma SE's - Neuropathy, SIADH DI - Avoid CYP 3A4 inhibitors or inducers Comments - Fatal if given intrathecally
Vincristine, Liposomal (Marquibo) MOA Indication SE's DI Comments
MOA - Inhibits microtubule formation
Indication - ALL
SE’s - Fever, constipation, myelsuppression, neuropathy
DI - Avoid CYP 3A4, PGP, ABCB1 inhibitors and inducers
Comments - Fatal if given intrathecally
Vorinostat (Zolinza) MOA Indication SE's DI Comments
MOA - Histone deacetylase inhibitor Indication - NHL SE's - diarrhea, edema, fatigue, hyperglycemia DI - Valproic acid Comments - Take with food