Antineoplastics Flashcards
Alemtuzumab MOA Indication SE's DI Comments
MOA - Anti CD52 MAB
Indication - CLL
SE’s - Immunosuppression, neutropenia, infusion related reactions
DI - Vaccines and immunosuppressants
Comments - interactions are not enzyme mediated
Arsenic Trioxide MOA Indication SE's DI Comments
MOA - Differentiating agent Indication - APL SE's - Differentiation syndrome, neuropathies DI - QT prolonging medications Comments - NA
Azacitidine MOA Indication SE's DI Comments
MOA - Hypomethylating agent Indication - AML, MDS SE's - Myelosuppression, nausea DI - Immune suppressants, echinacea Comments - Delayed onset of effect (2-4 cycles)
Belinostat MOA Indication SE's DI Comments
MOA - Histone deacetylase inhibitor Indication - Peripheral T-cell lymphoma SE's - Myelosuppression, nausea, fatigue DI -UGT1A1 and PGP inhibitors or inducers Comments - NA
Bendamustine MOA Indication SE's DI Comments
MOA - Alkylating agent Indication - CLL, NHL SE's - Myelosuppression, nausea, emesis DI - CYP 1A2 inhibitors Comments - N/A
Bleomycin MOA Indication SE's DI Comments
MOA - inhibits DNA and RNA synthesis Indication - HD, NHL SE's - Pulmonary toxicity, hyper pigmentation, Raynauds DI - Brentuximab vaccines Comments - Lifetime max dose 400 units
Blinatumomab MOA Indication SE's DI Comments
MOA - anti CD 19 MAB that links to cytotoxic T-cells
Indication - ALL
SE’s - Cytokine release syndrome, tumor lysis, leukoencephalopathy
DI - vaccines
Comments - murine antibody
Bortezomib MOA Indication SE's DI Comments
MOA - Proteasome inhibitor
Indication - Myeloma, NHL
SE’s - Neuropathy, diarrhea, thrombocytopenia
DI - CYP 3A4 inducers, green tea, CYP 2C19 substrates
Comments - SQ administration decreases neuropathy
Brentuximab vedotin MOA Indication SE's DI Comments
MOA - Anti-CD 30 MAB linked to microtubule inhibitor
Indication - HD
SE’s - Rach, neuropathy, myelosuppression
DI - Bleomycin, CYP 3A4 inhibitors or inducers
Comments - Dosing maxed at 100kg (dosed per kg)
Busulfan MOA Indication SE's DI Comments
MOA - Alkylating agent
Indication - CML, used for BMT
SE’s - Myelosuppression, hyperpigementation, n/v, lowers seizure threshold, veto-occlusive disease
DI - APAP, avoid CYP inhibitors and inducers
Comments - Prophylactic anticonvulsants used with BMT
Carboplatin MOA Indication SE's DI Comments
MOA - Platinum alkylating agent Indication - HD, NHL SE's - N/V, myelosuppression, neuropathy DI - Mesna, immune suppressants Comments - Dosed per GFR based on Calvert formula
Carfilzomib MOA Indication SE's DI Comments
MOA - Proteasome inhibitor Indication - myeloma SE's - heart failure, fatigue, nausea DI - PGP/BCRP inhibitors Comments - Dosed at maximum BSA 2.2m squared
Carmustine MOA Indication SE's DI Comments
MOA - Alkylating agent
Indication - HD, NHL
SE’s - Myelosuppression, pulmonary fibrosis, n/v
DI - immunosuppressants, vaccines
Comments - dissolved in dehydrated alcohol
Chlorambucil MOA Indication SE's DI Comments
MOA - Alkylating agent Indication - CLL SE's - myelosuppression, mucositis DI - Other myelosuppressive agents Comments - Take on empty stomach
Cisplatin MOA Indication SE's DI Comments
MOA - Platinum alkylating agent Indication - NHL, HD SE's - N/v, nephrotoxic, neuropathies DI - Concomitant nephrotoxins Comments - delayed nausea common
Cladribine MOA Indication SE's DI Comments
MOA - purine analog Indication - CLL, NHL, hairy cell leukemia SE's - infections, myelosuppression DI - live vaccines Comments - Needs PJP prophylaxis
Clofarabine MOA Indication SE's DI Comments
MOA - Purine analog Indication - ALL< AML SE's - Infections, myelosuppression, capillary leak syndrome DI - Live vaccines Comments - needs PJP prophylaxis
Cyclophosphamide MOA Indication SE's DI Comments
MOA - Alkylating agents
Indication - ALL, NHL, myeloma
SE’s - hemorrhagic cystitis, myelosuppression, SIADH
DI - CYP 2B6 inhibitors, CYP inducers
Comments - Mesna may be used as a bladder protectant
Cytarabine MOA Indication SE's DI Comments
MOA - Pyrimidine analogue
Indication - AML, NHL, HD
SE’s - Myelosuppression (high dose - conjunctivitis, cerebellar toxicity), acral erythema
DI - Concomitant immune suppressants
Comments - Steroid eye drops used with high dose
Dacarbazine MOA Indication SE's DI Comments
MOA - Alkylating agent
Indication - HD
SE’s - myeosuppression, n/v, photosensitivity
DI - CYP 1A2 oe 2E1 inhibitors or inducers
Comments - N/A
Daratumumab MOA Indication SE's DI Comments
MOA - AntiCD 38 MAB
Indication - myeloma
SE’s - infusion reactions, myelosuppression
DI - none
Comments - interferes with RBC cross-matching
Dasatinib MOA Indication SE's DI Comments
MOA - Inhibits BCR-ABL kinase Indication - CML, Ph+ALL SE's - Fluid retention, rash, myelosuppression, pleural effusion DI - CYP 3A4 inhibitors, acid reducers Comments - Taken w/o regards to food
Daunorubicin MOA Indication SE's DI Comments
MOA - DNA intercalator, free radical generation, topoisomerase II inhibitor
Indication- AML, ALL
SE’s - Vesicant, HF, arrhythmias, skin flare, urine discoloration, myelosuppression
DI - Avoid PGP and ABCB1 inducers or inhibitors
Comments - Lifetimes maximum of 500 mg/m squared suggested
Decitabine MOA Indication SE's DI Comments
MOA - Hypomethylating agent Indication - AML, MDS SE's - Myelosuppression, edema, nausea DI - N/A Comments - May take several cycles for full effect
Doxorubicin MOA Indication SE's DI Comments
MOA- DNA intercalator, free radical generation, topoisomerase II inhibitor
Indication - NHL, HD, myeloma
SE’s - Vesicant, HF, arrhythmias, skin flare, urine discoloration, myelosuppression
DI - Avoid CYO 3A4 and PGP inhibitors or inducers
Comments - Lifetime maximum of 550 mg/m squared suggested
Dexamethasone MOA Indication SE's DI Comments
MOA - Lympholytic corticosteroid
Indication - CLL, ALL, NHL, HD, myeloma
SE’s - Hyperglycemia, osteoporosis, mood changes, cataracts
DI - Inhibits multiple CYP enzymes so be aware of other substrates with narrow therapeutic margins
Comments - Take with food, infuse large doses slowly
Doxorubicin, Liposomal MOA Indication SE's DI Comments
MOA - DNA intercalator, free radical generation, topoisomerase II inhibitor
Indication - myeloma
SE’s - hand foot syndrome, arrhythmia, HF, myelosuppression, infusion reactions
DI - avoid CYP 3A4 inhibitors or inducers
Comments - lifetime max of 550 mg/m2 suggested
Elotuzumab MOA Indication SE's DI Comments
MOA - Anti SLAMF-7 MAB Indication - Myeloma SE's - N/A DI - M/A Comments - Premedicate with H1 and H2 blocker and APAP
Etoposide MOA Indication SE's DI Comments
MOA - Topoisomerase II inhibitor
Indication - NHL, AML, HD
SE’s - Myelosuppression, hypotension, nausea, stomatitis
DI - Avoid CYP 3A4 inhibitors and inducers
Comments - Infuse over 1 hour minimum
Fludarabine MOA Indication SE's DI Comments
MOA - Purine analog Indication - AML, CLL, NHL SE's - myelosuppression, encephalopathy, infections DI - Live vaccines Comments - Needs PJP prophylaxis
Gemtuzumab MOA Indication SE's DI Comments
MOA - Anti CD 33 MAB linked to an alkylating agent
Indication - AML
SE’s - Myelosuppression, veni-occlusive disease
DI - N/A
Comments - Light sensitive compound
Hydroxyurea MOA Indication SE's DI Comments
MOA - Ribonucleotide reductase inhibitor Indication - AML, ALL, CML SE's - Myelosuppression, cutaneous ulcers, hyperuricemia DI - N/A Comments - Take without regards to food