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Drugs > Antineoplastic Drugs > Flashcards

Antineoplastic Drugs Flashcards

0
Q

What new antineoplastic drugs are metabolized in the liver and are EGFR tyrosine kinase inhibitors?

A

Gefitinib/Erlotinib

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1
Q

What new antineoplastic drug acts as a tyrosine kinase inhibitor, has hepatic metabolism and has the following toxicity’s: Congestive heart failure, fluid retention

A

Imatinib (gleevic)

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2
Q

What new antineoplastic drug is a monoclonal antibody targeted against the EGFR-HER2 receptor and has the toxicity of cardiac dysfunction?

A

Trastuzumab (Herceptin)

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3
Q

What new antineoplastic drug is an angiogenesis inhibitor, causes peripheral neuropathy and blocks VEGF and BFGF?

A

Thalidomide

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4
Q

What new antineoplastic drug is a protease inhibitor, inhibits ubiquitin pathway and inhibits 26s proteosome and causes peripheral neuropathy?

A

Bortezomib

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5
Q

What classical DNA binding antineoplastic drug is an alkylator, requires 0 processing, uses IV administration and has the classical toxicity’s?

A

Mechlorethamine

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6
Q

What classical DNA binding antineoplastic drug is an alkylator, is a pro drug activated by the liver and has the toxicity’s of hemorrhage and cystitis?

A

Cyclophosphamide

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7
Q

What classical antineoplastic drug is a platinum analog, is injected via IV, has 0 metabolism, charged and has toxicity’s that affect the kidney and ear?

A

Cisplatin

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8
Q

What classical antineoplastic drug is an antibody, injected via IV, not metabolized and has the classical toxicity’s?

A

Actinomyocin (Dactinomyocin)

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9
Q

What classical antineoplastic drug is administered via IV, is an antibody, processed by liver into bile and has cardio toxicity’s?

A

Adriamyocin (Dexorubian)

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10
Q

What classical DNA binding antineoplastic drug causes skin lesions and pulmonary fibrosis?

A

Bleomycin

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11
Q

What classical DNA binding antineoplastic drug is a topoisomerase inhibitor, affects topoisomerase 2 and uses hepatic processing?

A

Etoposide

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12
Q

What classical DNA binding antineoplastic drug is a topoisomerase inhibitor, affects topoisomerase 1 and has the classic toxicity’s?

A

Irinutecan

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13
Q

What classical antineoplastic non DNA binding drug is an antimetabolite, folate analog,

A

Methyltrexate

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14
Q

What classical antineoplastic non DNA binding drug is a antimetabolite, purine analog, pro drug and causes bone marrow suppression?

A

6-Mercaptopurine

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15
Q

What classical antineoplastic non DNA binding drug is a antimetabolite, pyrimidine analog inhibitor, and causes bone marrow suppression?

A

5-flourocil (5-FU)

16
Q

What non DNA binding classical antineoplastic drug is a mitotic spindle inhibitor, destabilizes spindle liver process, and causes mylosuppression/bone marrow suppression?

A

Vinblastine

17
Q

What classical non DNA binding antineoplastic drug is a mitotic spindle inhibitor, destabilizes spindle, processed in liver, and cause CNS neurotoxicity?

A

Vinocristine

18
Q

What classical non DNA binding antineoplastic drug is a mitotic spindle inhibitor, stabilizes spindle, and is metabolized in the liver

A

Paditaxol

19
Q

What classical non DNA binding antineoplastic drug stimulates differentiation/maturation of cells?

A

Retinoic Acid

20
Q

What classical non DNA binding antineoplastic drug inhibits xamkin oxidase C

A

Allopurinol

21
Q

What non DNA binding antineoplastic drug is a hormone, GnRH agonist, that requires surge and decreases LH/FSH concentration

A

Leuprolide

22
Q

What non DNA binding antineoplastic drug is a hormone, GnRH antagonist, decreases LH?

A

Degarelex

23
Q

What non DNA binding antineoplastic drug is a hormone and estrogen agonist?

A

Estradiol

24
Q

What non DNA binding antineoplastic drug is a hormone and estrogen antagonist?

A

Tamoxifen

25
Q

What non DNA binding antineoplastic drug is a hormone and androgen agonist?

A

Danazol

26
Q

What non DNA binding antineoplastic drug is a hormone and androgen antagonist?

A

Flutamide

27
Q

What non DNA binding antineoplastic drug is a aromatase inhibitor?

A

Letrazole

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