Anti Inflammatory Drugs

Question 0

What antihistamine drugs block the action of histamine at H1 receptors, are commonly called antagonist but many are inverse agonists, have varying amounts of anticholinergic, anti-alpha-adrenergic, and anti-seratonergic actions?

Answer 0

Chlorpheniramine, diphenhydramine, promethazine

Question 1

What antihistamine drug is clinically used for allergic rhinitis and allergic conjunctivitis?

Answer 1

Chlorpheniramine (Chlor-Tabs)

Question 2

What antihistamine drug is clinically used for allergic rhinitis, allergic conjunctivitis, urticaria, sleep aide and motion sickness?

Answer 2

Diphenhydramine (Benadryl)

Question 3

What antihistamine drug is clinically used for allergic rhinitis, allergic conjunctivitis, urticaria, sleep aide, motion sickness, anti-emetic?

Answer 3

Promethazine (phenergan)

Question 4

What antihistamine drugs cause varying amounts of sedation (CNS effects mediated by H1 receptors), xerostomia (dry mouth), pupil dilation, blurred vision and urinary retention ( anti-cholinergric effects), orthostatic hypotension (anti-alpha-adrenergic effect)?

Answer 4

Chlorpheniramine, diphenhydramine, promethazine

Question 5

What antihistamine drugs have known hypersensitivity, are not for use in children less than 2 years of age; children may display signs of CNS stimulation/nervousness

Answer 5

Chlorpheniramine, diphenhydramine, promethazine

Question 6

What antihistamines are known as 1st generation antihistamines, have relatively short duration of action (3-6 hours), not for use in treatment of lower respiratory tract symptoms as in asthma?

Answer 6

Chlorpheniramine, diphenhydramine, promethazine

Question 7

What antihistamine drug just blocks the action of histamine at histamine H1 receptors (commonly called antagonists but many are reverse agonists)

Answer 7

Ioratadine (Claritin), fexofenadine (Allegra), cetirizine (Zyrtec)

Question 8

What antihistamine drugs are used clinically to treat allergic rhinitis, allergic conjunctivitis, urticaria, (including chronic idiopathic urticaria)?

Answer 8

Ioratadine (Claritin), fexofenadine (Allegra), cetirizine (Zyrtec)

Question 9

What antihistamine drugs cause dry mouth, high incidence of sedation and drowsiness?

Answer 9

Ioratadine (Claritin), fexofenadine (Allegra), cetirizine (Zyrtec)

Question 10

What antihistamine drugs have known hypersensitivity, not for use in children less than 2 years of age; children may display signs of CNS stimulation/nervousness, caution with co administration of certain anti fungal drugs ketocanazole, iracanazole and macrolide antibiotics (erythromycin, clarithromycin), may result in increased antihistamine in blood levels?

Answer 10

Ioratadine (Claritin), fexofenadine (Allegra), cetirizine (Zyrtec)

Question 11

What antihistamine drugs are 2nd/3rd generation antihistamine, produce less sedation than 1st generation antihistamine drugs due to reduced distribution into CNS, littler or no anti-cholinergic, anti-seratonergic, and anti-alpha-adrenergic activity, relatively long durations of action (12-24 hours), not useful for nausea or motion sickness?

Answer 11

Ioratadine (Claritin), fexofenadine (Allegra), cetirizine (Zyrtec)

Question 12

What type of drugs may cause GI dyspepsia and GI bleeding, reduce renal function and induce blood pressure, all may display cross-hypersensitivity reactions, excluding aspirin regular/chronic use of all of these types of drugs (and in particular with this that are selective for COX-2) is associated with increased risk for venous thromboembolism, may cause adverse (even fatal) dermatological reactions including exofoliative dermatitis and Stevens-Johnson’s syndrom?

Answer 12

NSAID’s

Question 13

What type of drugs have varying selectivity for inhibition of cyclooxygenase 1 and 2 COX-1, COX-2

Answer 13

NSAID’s

Question 14

What NSAID has anti-inflammatory, analgesic, anti-pyretic, and anti platelet effects?

Answer 14

Aspirin

Question 15

What NSAID causes GI dyspepsia, GI bleeding, tinnitus, dizziness?

Answer 15

Aspirin

Question 16

What NSAID causes allergy/hypersensitivity reaction and use in patients with varicella infection or influenza virus may cause Reye’s syndrome?

Answer 16

Aspirin

Question 17

What RA drug has actions that contribute to anti inflammatory activity, increase the plasma levels of penicillamine, which is also used to treat RA, increasing the side affects of that drug, relatively slow and has limited activity by itself, often combined with other therapies, anti malarial drug, also used to treat SLE?

Answer 17

Hydroxychloroquine

Question 18

What RA drug is a soluble TNFa receptor fusion protein: blocks TNFa action?

Answer 18

Etanercept

Question 19

What RA drug is an anti TNFa antibody: blocks TNFa action?

Answer 19

Infliximab

Question 20

What drug is commonly giving in conjunction with infliximab?

Answer 20

Methotrexate

Question 21

What RA drug inhibits IL-1 function and should not be given in combination with TNFa inhibitors because of increased incidence of severe effects?

Answer 21

Anakinra

Question 22

What two drugs are TNFa inhibitors?

Answer 22

Etanercept

Infliximab

Question 23

What RA drug prevents CD28 from binding to its counter receptor B7, powder for the drug contains maltose which may result in falsely elevated serum glucose readings on the day of infusion?

Answer 23

Abatecept

Question 24

What RA drug is a mab against the CD20 antigen which leads to B cell depletion, also used to treat B cell lymphoma/leukemia

Answer 24

Rituximab

Question 25

What RA drug is a JAK inhibitor, and may result in dosage adjustment in patients with renal impairment?

Answer 25

Tofacitinib

Question 26

What SLE drug is a purine analog, inhibits purine metabolism and is a pro drug?

Answer 26

Azathiorprine

Question 27

What SLE drug is an alkylation agent, cross links DNA leading to cell death, can lead to hemorrhage in bladder?

Answer 27

Cyclophosphamide

Question 28

What SLE drug inhibits IMP dehydrogenase and is expensive?

Answer 28

Mycophenolate mofetil

Question 29

What acute gout drug inhibits microtubule assembly, suppress inflammasome driven caspase 1 activation, IL-1beta processing and release, and L selectin expression, used in patients with NSAID intolerance?

Answer 29

Colchicine

Question 30

What chronic gout drug is a Xanthine oxidase inhibitor - inhibits uric acid synthesis, first pharmacologic treatment for recurrent gout?

Answer 30

Allopurinol

Question 31

What chronic gout drug is a Xanthine oxidase inhibitor, has incidence of liver function test abnormalities, more expensive than allopurinol?

Answer 31

Febuxostat

Question 32

What chronic gout drug promotes renal clearance of uric acid by inhibiting rate anion exchangers in the proximal tubule that mediates urate re absorption, increases urate excretion?

Answer 32

Probenecid

Question 33

What chronic gout drug is a recombinant uricase, which converts uric acid to allantoin, contradictive in patients with glucose-6- phosphate dehydrogenase (G6PD) deficiency

Answer 33

Pegloticase