Antineoplastic Antibiotics

Question 1

Antineoplastic Antibiotics prototype

Answer 1

Doxorubicin

Question 2

Doxorubicin indications

Answer 2

To produce regression in acute lymphoblastic lymphoma, acute myeloblastic leukemia, Wilms tumor, neuroblastoma, soft tissue and bone sarcoma, breast carcinoma, ovarian carcinoma, thyroid carcinoma, Hodgkin and non-Hodgkin lymphomas, bronchogenic carcinoma; also to treat AIDS-related Kaposi sarcoma.

Question 3

Doxorubicin actions

Answer 3

Binds to DNA and inhibits DNA synthesis in susceptible cells, causing cell death.

Question 4

Doxorubicin route, onset, peak, duration

Answer 4

IV, rapid, 2 h, 24-36 h

Question 5

Doxorubicin adverse effects

Answer 5

Cardiac toxicity, complete but reversible alopecia, nausea, vomiting, mucositis (painful inflammation and ulceration of the mucous membranes lining the digestive tract), red urine, myelosuppression, fever, chills, rash.