Alkylating Agents Flashcards
1
Q
Alkylating Agents prototype
A
Chlorambucil
2
Q
Chlorambucil indications
A
Palliative treatment of chronic lymphocytic leukemia, malignant lymphomas, and Hodgkin disease.
3
Q
Chlorambucil actions
A
Alkylates cellular DNA, interfering with the replication of susceptible cells.
4
Q
Chlorambucil route, onset, peak, duration
A
Oral, varies, 1 h, 15-20 h
5
Q
Chlorambucil adverse effects
A
Tremors, muscle twitching, confusion, nausea, hepatotoxicity, bone marrow suppression, sterility, cancer.
