Antimuscarinic drugs

Question 1

Name all antimuscarinic drugs available ?

Answer 1

oxybutinin
tolteridone
fesoterodine
darifenacin
solifenacin
flavoxate
propantheline bromide
propiverine
trospium

Question 2

What are the common/very common s/e of antimuscarinic drugs ?

Answer 2

Constipation; dizziness; drowsiness; dry mouth; dyspepsia; flushing; headache; nausea; palpitations; skin reactions; tachycardia; urinary disorders; vision disorders; vomiting

Question 3

When would antimuscarinic drugs be contraindicated ?

Answer 3

Angle-closure glaucoma; 
gastro-intestinal obstruction; 
intestinal atony; 
myasthenia gravis (but some antimuscarinics may be used to decrease muscarinic side-effects of anticholinesterases); 
paralytic ileus; 
pyloric stenosis; 
severe ulcerative colitis; s
ignificant bladder outflow obstruction; 
toxic megacolon; 
urinary retention

Question 4

what are common/very common side effects of oxybutinin ?

Answer 4

diarrhoea and dry eyes.

Question 5

What are common/very common side effects of oxybutinin when used as a transdermal patch ?

Answer 5

gastrointestinal discomfort and increased risk of infection.

Question 6

What are common/very common side effects of tolteridone ?

Answer 6

abdominal pain, bronchitis, chest pain, diarrhoea, dry eye, fatigue, gastrointestinal disorders, paraesthesia, peripheral oedema, vertigo, and weight gain.

Question 7

How should oxybutinin patches be used ?

Answer 7

Manufacturer advises apply patches to clean, dry, unbroken skin on abdomen, hip or buttock; remove after every 3–4 days and site replacement patch on a different area (avoid using same area for 7 days).

Question 8

If a patient has Gastro-intestinal haemorrhage can flavoxate be prescribed ?

Answer 8

NO