Antimicrotubules Flashcards
T/F: Antimicrotubules target mitosis
True
What is the rational behind targeting microtubules
Microtubules are essential for chromosome seperation therefore interfering with mitotic spindles may provide an approach to disrupt mitosis in cancer cells
What do microtubules do in nerve cells
Transport organelles
What some examples of drugs that effect polymerization of microtubules used as anti-cancer agents
Taxol, Vinblastine, cochicine
What are microtubules composed of, what is the purpose of GTP
heterodimer alpha-tubulin and beta tubulin/ in alpha-tublin strictly structural and beta-tubulin as factors for growth
T/F: When GTP is hydrolyzed the microtubule no longer grows but instead shrinks and curves destabilizing the the ends
True
Why is dynamic instability
Coexistence of assemby and disassembly at the ends of microtubules (dynamcally switch between growing and shrinking)
What is a catastophe factor of microtubules, stabilization
kinesin-13 and XMAP215
What does gamma-tubulin do
ORganising center of microtubule assembly
T/F: Microtubles grow at the plus side
True
What is the key point in how mitosis is regulated
Anaphase Promoting Complex (APC) is activated by Cdc20 to target securin for ubiquityulation and degradation in order for separase to digest cohesion of chormosomes
What is the difference between taxanes and vincas
Taxanes stabilize and vincas destabilize
What are the vincas
Vinablastine, vincristine and vinorelbine
What are the two major units of vincas
Catharanthin and vindoline
T/F: Vinca compounds work best when given intrathecally
False: Vinca compounds CANNOT be administerred INTRATHECALLY
