Antimetabolites Flashcards
What are antimetabolites?
Chemicals that inhibit action of metabolites therefore, INTERFERE WITH NORMAL METABOLISM
What phase of the cell cycle do antimetabolites act in
S phase: synthesis and replication of DNA
What is the two major mechanisms of antimetabolits
INHIBIT PRODUCTION of dexoyribonucleoside triphosphates (inhibits the replication of the DNA), INCORPORATE INTO THE DNA (cytotoxic effect on the cell)
What are the three different types of antimetabolites
Anti-purines, anti-folates, and anti-pyrimidines
What pathway for synthesizing DNA/RNA does tumors rely on
De novo pathway
What are the purines, pyrimidines
Adenine and guanine/ cytosine, uracil, and thymine
What are the two major anti-purines and what do they substitute for
6-mercatopurine (6-MP) –> Adenosine
6-thioguanine (6-TG) –> Guanine
What is the breaking point in the De novo purine nucleotide biosythensis
Inosine monophosphate
What are the two MOAs of anti-purines
Inhibit nucleotide synthesis at several step of de novo biosynthesis, incorporation into nucleic acids
Which antipurine blocks IMP from being converted to AMP
6-MP
T/F: When anti-purines are incorportated into DNA the repair pathways have trouble distinguishing them from regular purines but DNA/RNA polymerase never replicate them
True
What are the side effects of 6-MP
fatigue, diarrhea, nausea, skin rash, alopecia
What are the side effects of 6-TG
leukopenia, neutropenia, thrombocytopenia, anemia, anorexia
What are the two groups for anti-pyrimidines
Cytdine analogs and fluropyrimidine analogs
What are the cytdine analogs, fluropyrimindine analogs
Cytarabine and gemcitabine/ 5-flurouracil and capecitabine