Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Oncology > Antimicrotubules > Flashcards

Antimicrotubules Flashcards

1
Q

types of antimicrotubules

A

Inhibition of Polymerization
- Colchicine
- Vinca alkaloids
(vincristine, VInblastine, vinorelbine)

Inhibition of Depolymerization:
- Taxanes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MOA of antimicrotubule

A

MOA: Binds to tubulin, a protein that compromised of alpha and beta subunits, inhibit its polymerization. (Polymerization of tubulin is responsible for the formation of the mitotic spindle during the metaphase period of mitosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Vinca-Induced Toxicities

A

In general..
•All vincas have very low emetogenic potential! •Vesicants!
•Alopecia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Vincristine toxicities

A

Vincristine
•Peripheral neuropathy: maximum dose is 2 mg weekly •Ileus, constipation
•Rarely causes bone marrow suppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Vinblastine and Vinorelbine toxicities

A

Vinblastine and Vinorelbine
•Dose limiting neutropenia and thrombocytopenia
•Neurologic toxicity and constipation can also occur but much lesst han vincristine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

When should we adjust dose if pt take vinca alkaloid?

A
  • ## MUST adjust doses when patient experiences hepatic dysfunction!
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Vinca alkaloid interaction cyp

A

Many drug interactions (substrate for CYP3A4)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Antidote for vesicant effect in vinca alkaloid

A
  • Agents are potent vesicants, apply warm pack and administer hyaluronidase 1ml as an antidote
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

__________ administration of vinca alkaloid is fatal.

A

Intrathecal administration of these agents is FATAL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Taxanes MOA

A

Mechanism of action: similar to vincas; except the taxanesbind preferentially to the microtubules shifting the microtubules towards polymerization –the taxanesthen stabilize against depolymerization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Taxanes require ___________________

A

Premedications Required for Taxanes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

taxanes drugs

A

(Paclitaxel, Docetaxel, Ixabepilone)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Premedication for Paclitaxel

A

Paclitaxel (Taxol®, Anzatax®)

  • PREMEDICATIONS for Hypersensitivity
  • Give H1-blocker, H2-blocker, Corticosteroids
  • If given Albumin stabilized anoparticle version (Abraxane®) –no premed required !
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Premed for Docetaxel

A

Docetaxel(Taxotere®)

  • PREMEDICATIONS for Edema
  • Give Dexamethasone starting on the day before chemo
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

premed for Ixabepilone

A

Ixabepilone (Ixempra®)

  • PREMEDICATIONS for Hypersensitivity
  • Give H1 and H2 blockers: Diphenhydramine 50 mg and Ranitidine 150-300 mg PO 30 minutes before treatment
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Toxicities of taxanes

A

Toxicities (frequency of administration affect types of SE)

  • Neuropathy
  • Lacrimation
  • Myalgia
  • Arthralgia
  • Fatigue
  • Neutropenia
  • Infection
  • Stomatitis

Oncology (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions