Antimicrobials

Question 1

daptomycin MOA

Answer 1

depolarization

Question 2

daptomycin contraindications

Answer 2

pneumonia
(inactivated by surfactant)

Question 3

aztreonam indications

Answer 3

Gm- aerobes
(pseudomonas)

Question 4

cilastin

Answer 4

prevents inactivation of imipenem

Question 5

carbapenem indications

Answer 5

Gm- infections (caused by empirical Tx resistant bacteria)

Question 6

chloramphenicol relevance

Answer 6

meningitis (developing countries)

Question 7

griseofulvin MOA

Answer 7

bind microtubules to prevent division

Question 8

terbinafine relevance

Answer 8

dermatophyte infection

Question 9

___ inhibits squalene epoxidase

Answer 9

terbinafine

Question 10

___ block glucan synthesis

Answer 10

echinocandins

Question 11

IV echinocandin relevance

Answer 11

systemic candidiasis

Question 12

-pravir

Answer 12

NS3/4A protease inhibitor
(HCV)

Question 13

-asvir

Answer 13

NS5A protease inhibitor
(HCV)

Question 14

-buvir

Answer 14

NS5B protease inhibitor
(HCV)

Question 15

gancyclovir MOA

Answer 15

same as acyclovir
(needs phosphorylated to function)

Question 16

gancyclovir adverse reactions

Answer 16

myelosuppression

Question 17

foscarnet and cidofovir relevance

Answer 17

does NOT require phosphorylation

Question 18

foscarnet and cidofovir adverse effect

Answer 18

renal toxicity