Antimicrobial Review w/ Schoeny Flashcards
List the Beta Lactams
Penicillins
Extended spectrum penicillins
Cephalosporins
Carbapenems
List the Non Beta Lactams
Macrolides Tetracyclines Clindamycin Aminoglycocides Fluoroquinolones Nitrofurantoin Sulfonamides
Natural PCNs
- Penicillin G(IV or IM) or Penicillin VK (PO)
- Benzathine Penicillin (long-acting IM)
Penicillin G or PCN VK is commonly used to treat?
-Strep pharyngitis/cellulitis
_______ is used to treat Syphilis
Benzathine Penicillin (Bicillin LA)
Primary Syphilis Sx:
sore or sores at the original site of infection. These sores usually occur on or around the genitals, around the anus or in the rectum, or in or around the mouth, sores are firm/round/ painless.
Secondary Syphilis Sx:
maculopapular skin rash, swollen lymph nodes, and fever. Money spots on palms of hands/feet
List the Aminopenicillins
Ampicillin(IV) or amoxicillin (po)
What do aminopenicillins cover?
Coverage: Strep pyogenes (group A strep infections), Strep agalactaie, Strep pneumonia, Enterococci, Borrelia burgdorferi, Listeria
Aminopenicillins: commonly used to treat?
Pharyngitis, sinusitis, otitis media, endocarditis prophylaxis, Lyme dx (age <8 years)
Anti-staph PCNs:
-list two and their formulations
Nafcillin (IV) or dicloxacillin (PO)
Anti-Staphylococcal Penicillins
are commonly used to treat?
Skin and soft tissue infections with suspected Staph but works against Strep as well
Child (7 yo) was recently diagnosed with lyme disease. What tx is appropriate?
amoxicillin for kids <8 yo
borrelia burgdorferi
Where does listeria originate?
-What is Listeria’s WORST complication?
contaminated soft cheeses like brie—or cantaloupe in CO! and unpasteurized dairy products. Listeria is a food borne illness that causes diarrhea, severe dehydration, the worst complication is Meningitis!!!!!!! Esp young kids/elderly. It can also cause miscarriages in pregnancy –if someone presents to the ER with meningeal symptoms and there has been a listeria outbreak– MUST give them an aminopenicillin
Are Nafcillin (IV) or dicloxacillin (PO) good for MRSA infections?
NO, minimal staph coverage
List the Augmented Aminopenicillins
Ampicillin/sulbactim (Unasyn IV) or amoxicillin/clavulanate (Augmentin PO)
Coverage for the Augmented Aminopenicillins:
Same as aminopenicillins plus Pasteurella, Moraxella, Haemophilus influenza, anaerobes
Augmented Aminopenicillins are MC used to treat:
- Bites
- Otitis media, sinusitis, acute exacerbation of chronic bronchitis
- Dental infections
- Skin and soft tissue infections
**Pasteurella from animal bites!!! (cat and dog), respiratory infections like bacterial sinusitis
COPD—acute exacerbations of bronchitis-–H influenzae is BIG player
Skin and soft tissue infections BUT NO MRSA coverage
Augmented Extended-Spectrum Penicillins: list
-coverage and typical Pt population this abx is used?
- Piperacillin/tazobactam (Zosyn IV)
- *Broad spectrum w/ Pseudomonas coverage–> think hospitalized Pts!
- Zoysn is broad spectrum– gram + and – and good pseudamonas coverage, used in hospital Pts, BUT no MRSA coverage
PCNs MOA:
stops cell wall synthesis by binding penicillin binding protein
PCNs MOR:
B lactamases and PBP alterations
PCNs Pharmacology
- Renal
- Bacteriocidal
Bacteriostatic vs bacteriocidal
Bacteriostatic: slows growth of the bacteria, but doesn’t kill it all off, relies on working with the Pt’s immune system to also help fight the infection
Vs
Bacteriosidal: KILLS the bacteria, so it cant mutate
PCNs
-List ADRs (clavulanate is associated with _____**)
- Hypersensitivity Reactions
- Clavulanate assoc. w/ diarrhea and subclinical hepatotoxicity
Cephalosporins are classified by:
generations! 1st-5th
Cephalosporin generalized rule regarding the generations and coverage:
- 1st generation has excellent gram positive activity and poor gram negative activity.
- Gram positive activity decreases as generations increase
- Gram negative activity increases as generations increase
- 4 generations + next generation
EXCEPTION to the cephalosporin rule
** Next generation(ceftaroline) has broad coverage AND MRSA coverage
Cephalosporins: MOA
stops cell wall synthesis by binding penicillin binding protein
Cephalosporins: MOR
beta-lactamases
Cephalosporins: ADR
Ceftriaxone (3rd gen) linked with biliary sludging /pseudocholelithiasis
List the 1st gen cephalosporins and formulations
Cefazolin (Ancef IV) or cephalexin (Keflex po)
1st gen cephalosporins: coverage?
- *Coverage: gram positives excellent EXCEPT MRSA, minimal gram negative coverage
- Strep pyogenes, MSSA
- Some E coli, Klebsiella, Proteus
1st gen cephalosporins:
Common tx indications?
- Skin and soft tissue infections
- Strep pharyngitis
- Pre op prophylaxis (cefazolin)
- Uncomplicated cystitis
2nd Generation cephalosporins: list
Cefuroxime (Ceftin po)
Cefuroxime (ceftin) coverage ?
Covers same as 1st generation (gram positives excellent EXCEPT MRSA, minimal gram negative coverage) plus Strep pneumonia, Moraxella catarrhalis, Haemophilus influenza (respiratory)
2nd Generation cephalosporins: Common tx indications?
(Cefuroxime) Otitis media Sinusitis -Acute exacerbations of chronic bronchitis -Skin and soft tissue infections
3rd generation cephalosporins: list
Ceftriaxone (Rocephin IM or IV), cefdinir (Omnicef PO)
3rd generation cephalosporins: coverage?
gram negative with some gram positive- NOT enterococcus or MRSA
**Ceftriaxone crossed blood brain barrier–> can be used for empiric meningitis tx (BUT not for listeria meningitis) . Also good for CAP and gonorrhea
3rd generation cephalosporins: common tx indications
CAP
Meningitis
Gonorrhea (with Azithromycin)
Pyelonephritis
New tx regimen for chlamydia and gonorrhea
New tx for gonorrhea– ceftriaxone 500 mg IM by itself NO azithromycin
Same with chlamydia– now doxycycline 100 mg PO BID x 7 days is TOC for chlamydia. *Azithromycin is now alternative
4th generation Cephalosporins: list
Cefepime (IV)
4th generation Cephalosporins: coverage
most gram negative rods, more resistant gram negatives>Pseudomonas
**4th gen MC used in hospital setting (cefepime IV)
5th gen cephalosporin: list
Ceftaroline(Teflaro IV)
5th gen cephalosporin: coverage?
- very broad gram negative and gram positive coverage
- **MRSA coverage
-Pneumonia and skin and soft tissue infections
BUT NO pseudomonas
Tetracyclines: list
Tetracycline, minocycline, doxycycline (PO,IV)
Tetracyclines: coverage
Step pneumo, Moraxella catarrhalis, H influenza, Chlamydia, Legionella, Mycoplasma, Rickettsia, Ehrlichia, Borellia, Staph aureus including MRSA
Tetracyclines: MOA**
protein synthesis inhibition at **30 S bacterial ribosome
MOR:efflux pump
Tetracyclines: MOR
-pharmacology?
efflux pump
Pharmacology:
Split excretion
bacteriostatic
Tetracyclines: ADRs
- Photosensitivity
- **Contraindicated in pregnancy/kids <8 years of age
Tetracyclines: common tx indications
Sinusitis Acute Exacerbations of chronic bronchitis CAP Non gonococcal urethritis/cervicitis TICK BORNE disease (Lyme, Rickettsia)
Tetracyclines SHOULD NOT be combined with ______
**isotretinoin–>can cause pseudotumor cerebri
______ decreases tetracyclines absorption
calcium
**do not let pts take calcium supplements
Macrolides: list
Azithromycin, clarithromycin, erythromycin ( po or IV)
Macrolides: coverage
Strep pneumo, Strep pyogenes, Moraxella catarrhalis, H influenza, **Chlamydia, Mycoplasma, H pylori, and **pertussis
pertussis= azithromycin
Macrolides: MOA
protein synthesis inhibition at **50S ribosome
Macrolides: MOR
ribosomal changes and efflux pump