Antimicrobial Drugs

Question 1

Aminoglycosides

Answer 1

bacteriocidal

Target protein synthesis and RNA proofreading causing damage to cell membrane

Question 2

Rifampicin

Answer 2

bacteriocidal

Targets RopB subunit of RNA polymerase

Question 3

What are the side effects of rifampicin

Answer 3

make secretions go orange/red - affects compliance

Question 4

Vancomycin

Answer 4

bacteriocidal

targets lipid II components of cell wall biosynthesis as well as wall crosslinking via D-ala residues

Question 5

Linezolid

Answer 5

bacteriostatic

Inhibits the initiation of protein synthesis by binding to 50s rRNA subunit of gram-positive bacteria

Question 6

Daptomycin

Answer 6

bacteriocidal

Targets cell membrane of gram-positive bacteria

Question 7

Beta-lactams

Answer 7

bacteriocidal

Interfere with the synthesis of peptidoglycan component of the cell wall by binding to penicillin-binding proteins

Question 8

Macrolides

Answer 8

Targets 50s ribosomal subunit preventing amino-acyl transfer and thus truncation of polypeptides

Question 9

Quinolones

Answer 9

bacteriocidal

Target DNA gyrase in gram negative bacteria and topoisomerase IV in gram psotive bacteria

Question 10

Prontosil

Answer 10

bacteriostatic
First example of a sulphonamide antibiotic
Used to treat UTIs, RTIs and prophylaxis for HIV+ individuals

Question 11

What are two examples of aminoglycosides

Answer 11

Gentamicin and Streptomycin