Antimicrobial Classes: Viral

Question 1

Fusion Drugs

Answer 1

HIV Antiviral Therapy:
Attachment: Maraviroc
Penetration: Enfuvirtide

Question 2

Reverse Transcriptase Inhibitors

Answer 2

HIV Antiviral Therapy:
NRTIs: Tenofovir (TDF), Emtricitabine (FTC), Abacavir (ABC), Lamivudine (3TC), Zidovudine (ZDV), Didanosine (ddl), Stavudine (d4T)
NNRTIs: Nevirapine, Efavirenz, Delavirdine

Question 3

Integrase Inhibitors

Answer 3

HIV Antiviral Therapy:

Raltigravir

Question 4

Protease Inhibitors

Answer 4

HIV Antiviral Therapy:

Lopinavir, Atazanavir, Darunavir, Fosamprenavir, Saquinavir, Ritonavir, Indinavir

Question 5

Protein Synthesis Drugs

Answer 5

Interferon-alpha (used for HBV, HCV)

Question 6

Uncoating Drugs

Answer 6

Amantradine, Rimantadine (no longer useful for influenza due to resistance)

Question 7

Nucleic Acid Synthesis

Answer 7

Guanine nucleotide synthesis: Ribavirin (RSV, HCV)
Viral DNA polymerase inhibitors: Foscarnet, Cidofovir (CMV, HSV)
Guanosine analogs: Acyclocir, etc (HSV, VZV), Ganciclovir (CMV)

Question 8

Release of Progeny Virus Drugs

Answer 8

Neuraminidase inhibitors: Zanamivir, Oseltamivir (Influenza A, B)