Antimicrobial Agents Flashcards
1
Q
Ampicillin
A
PO IV IM B lactam (aminopenicillin)
2
Q
Amoxicillin
A
PO B lactam (aminopenicillin)
3
Q
Piperacillin
A
IV B lactam (anti-pseudomonal penicillin)
4
Q
Ceftraixone
A
IV IM
3rd gen cephalosporin
5
Q
Ceftazidime
A
IV IM
3rd gen cephalosporin
6
Q
Cefepime
A
IV IM
4th gen cephalosporin
7
Q
Meropenem
A
IV
carbapenem
8
Q
Ertapenem
A
IV IM
carbapenem
9
Q
Ampicillin-sulbactam
A
IV
B lactamase inhibitor
10
Q
Amoxicillin-clavulanic acid
A
PO
B lactamase inhibitor
11
Q
Piperacillin-tazobactam
A
IV
B lactamase inhibitor
12
Q
Vancomycin
A
PO IV
glycopeptide
13
Q
Ciprofloxacin
A
PO IV topical
fluoroquinolones (FQ)
14
Q
Levofloxacin
A
PO IV topical
FQ
15
Q
Gentamicin
A
IV IM topical
Aminoglycoside
16
Q
Moxifloxacin
A
PO IV topical
FQ
17
Q
Doxycycline
A
PO IV
tetracycline/glycylcycline
18
Q
Azithromycin
A
PO IV topical
“Z-pak”
macrolide/ketolide
19
Q
Clindamycin
A
PO IV IM topical
lincosamide
20
Q
Linezolid
A
PO IV
oxazolidinone
21
Q
Oseltamivir
A
PO
antiviral
22
Q
Fluconazole
A
PO IV
antifungal
23
Q
Itraconazole
A
PO IV
antifungal
24
Q
Voriconazole
A
PO IV
antifungal
25
Penicillins
MOA: inhibits the transpeptidation rxn (last step in peptidoglycan sythesis) --> inhibits cell wall synthesis
26
Cephalosporins
MOA: inhibits the transpeptidation rxn (last step in peptidoglycan sythesis) --> inhibits cell wall synthesis
1st gen = good GPB coverage, modest GNB coverage
2nd gen = good GNB coverage
3rd gen = best GNB coverage (esp Enterobacteriae)
4th gen = biggest spectrum, used in serious infxns
27
Carbapenems
MOA: inhibits the transpeptidation rxn (last step in peptidoglycan sythesis) --> inhibits cell wall synthesis
28
B lactamase inhibitors
MOA: inhibits B lactamases so B lactams can stop cell wall synthesis
29
Fluoroquinolones (FQ)
MOA: targets bacterial DNA gyrase and topoisomerase --> stops DNA replicaiton and transcription
30
Glycopeptides
MOA: inhibits cell wall synthesis by binding D-Ala-D-Ala terminal section of cell wall precursor units
31
Aminoglycoside
MOA: binds 30S ribosome --> stops protein synthesis
32
Macrolides/ketolides
MOA: binds 50S ribosome --> stops protein synthesis
33
Lincosamides
MOA: binds 50S ribosome --> stops protein synthesis
34
Oxazolidinones
MOA: binds 50S ribosome --> stops protein synthesis
35
Tetracyclines/Glycylcyclines
MOA: binds 30S ribosome --> stops protein synthesis
