Adrenergic antagonists

Question 1

phenoxybenxamine

Answer 1

non-selective alpha blocker
non-competitive
binds covalently –> any dose of sympath agonist = ineffective until drug metabolized (t 1/2 = 24 hrs)
also blocks histamine, ACh, and serotonin Rs
treats pheochromocytoma, PVD, raynauds sx

Question 2

phentolamine

Answer 2

non-selective alpha blocker

competitive –> reversible

Question 3

prazosin

Answer 3

alpha 1 selective –> therefore allows alpha 2 to continue to inhibit NE release –> fewer incidences of reflex bradycardia
treats HTN

Question 4

tamsulosin

Answer 4

alpha 1A selective –> allows blockade of prostatic smooth mm contraction
treats HTN, BPH

Question 5

propranolol

Answer 5

non-selective beta blocker
lipid soluble –> enters CNS
treats angina pectoris, HTN, migraine, arrhythmias, pheochromocytoma, thyrotoxicosis, anxiety, decrease mortality after AMI
can mask signs of hypoglycemia in DM pts

Question 6

atenolol

Answer 6

cardioselective beta 1 blocker
treats HTN, chronic stable angina
allows normal response to hypoglycemia

Question 7

acebutolol

Answer 7

cardioselective beta 1 blocker

treats HTN and dysrhythmias

Question 8

metoprolol

Answer 8

cardioselective beta 1 blocker

treats HTN

Question 9

betaxolol

Answer 9

beta 1 selective blocker

treats glaucoma and HTN

Question 10

labetalol

Answer 10

selective alpha 1 and non-selective beta 1 and 2 antagonist

treats HTN, pheochromocytoma

Question 11

carvedilol

Answer 11

non-selective beta antagonist 
reduces mortality in pts w/ stable class II or class III CHF