Antimicrobial Flashcards
Chemotherapy
Use of drugs to treat disease
Types of bacteria
Gram positive or gram negative
Gram positive bacteria have a thick peptidoglycan wall with no outer lipid layer. Gram negative have thin peptidoglycan wall with outer lipid layer
Mechanisms of antibiotics
Inhibition of cell wall synthesis (penicillin)
Inhibition of protein synthesis
Inhibition of nucleic acid replication and transcription
Breakdown of plasma membrane
Inhibition of enzymes producing essential metabolites
Beta lactamase
Enzyme that inactivates penicillin by breaking beta lactam ring
Antibiotics may be given with beta lactamase inhibitors
How bacteria become antibiotic resistance
Prevent entry
Break down antibiotic
Alter receptor antibiotic binds to
Expels antibiotic