Antimalarial Treatment Guide Flashcards

1
Q

Uncomplicated malaria
P. falciparum
No known resistance

A

Chloroquine/ Hydroxychloroquine

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2
Q

UNCOMPLICATED MALARIA
P.falciparum
Chloroquine-resistant or unknown

A
  • Atovaquone-proguanil (Malarone)
  • Artemether-lumefantrine (Coartem)
  • Quinine + doxycycline
  • Mefloquine
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3
Q

UNCOMPLICATED MALARIA
P.malariae
All regions
(no known resistance )

A

Chloroquine/ Hydroxychloroquine

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4
Q

UNCOMPLICATED MALARIA
P.vivax or P.ovale
All regions
(little resistance reported)

A

Chloroquine/ Hydroxychloroquine

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5
Q

UNCOMPLICATED MALARIA
P.vivax or P.ovale
Chloroquine-resistant

A
  • Atovaquone-proguanil (Malarone)
  • Artemether-lumefantrine (Coartem)
  • Quinine + doxycycline
  • Mefloquine
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6
Q

Anti relapse drug for all uncomplicated malaria treatments

A

Primaquine

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7
Q

UNCOMPLICATED MALARIA in PREGNANCY
P.vivax, P.ovale,P.falciparum ,P.malariae
Chloroquine resistant

A
ALL trimesters:
1. Quinine + clindamycin* 
2. Mefloquine
2nd – 3rd trimesters:
Artemether-lumefantrine (Coartem)
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8
Q

UNCOMPLICATED MALARIA in PREGNANCY
P.vivax, P.ovale,P.falciparum ,P.malariae
Chloroquine sensitive

A

Chloroquine /Hydroxychloroquine

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9
Q

SEVERE MALARIA

P.vivax P.ovale P.falciparum P.malariae

A

Option 1: IV Quinidine + doxycycline/ clindamycin then transfer to Oral quinine + doxycycline

Option 2: 
IV Artesunate then switch to Oral treatment of:
• Atovaquone-proguanil (Malarone)
• Artemether-lumefantrine (Coartem) 
• Quinine
• Mefloquine- last resort!
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10
Q

SEVERE MALARIA in PREGNANCY

A
1st trimester:
Quinidine or Artesunate
2nd – 3rd trimesters:
1. Artesunate 
2. Artemether
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11
Q

Treatment for CHEMOPROPHYLAXIS

Chloroquine resistant

A

Primaquine
Atovaquone-Proguanil (Malarone)
Mefloquine
Doxycycline

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12
Q

CHEMOPROPHYLAXIS for PREGNANCY

Chloroquine resistant

A

Mefloquine

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