Antimalarial Treatment Guide Flashcards
Uncomplicated malaria
P. falciparum
No known resistance
Chloroquine/ Hydroxychloroquine
UNCOMPLICATED MALARIA
P.falciparum
Chloroquine-resistant or unknown
- Atovaquone-proguanil (Malarone)
- Artemether-lumefantrine (Coartem)
- Quinine + doxycycline
- Mefloquine
UNCOMPLICATED MALARIA
P.malariae
All regions
(no known resistance )
Chloroquine/ Hydroxychloroquine
UNCOMPLICATED MALARIA
P.vivax or P.ovale
All regions
(little resistance reported)
Chloroquine/ Hydroxychloroquine
UNCOMPLICATED MALARIA
P.vivax or P.ovale
Chloroquine-resistant
- Atovaquone-proguanil (Malarone)
- Artemether-lumefantrine (Coartem)
- Quinine + doxycycline
- Mefloquine
Anti relapse drug for all uncomplicated malaria treatments
Primaquine
UNCOMPLICATED MALARIA in PREGNANCY
P.vivax, P.ovale,P.falciparum ,P.malariae
Chloroquine resistant
ALL trimesters: 1. Quinine + clindamycin* 2. Mefloquine 2nd – 3rd trimesters: Artemether-lumefantrine (Coartem)
UNCOMPLICATED MALARIA in PREGNANCY
P.vivax, P.ovale,P.falciparum ,P.malariae
Chloroquine sensitive
Chloroquine /Hydroxychloroquine
SEVERE MALARIA
P.vivax P.ovale P.falciparum P.malariae
Option 1: IV Quinidine + doxycycline/ clindamycin then transfer to Oral quinine + doxycycline
Option 2: IV Artesunate then switch to Oral treatment of: • Atovaquone-proguanil (Malarone) • Artemether-lumefantrine (Coartem) • Quinine • Mefloquine- last resort!
SEVERE MALARIA in PREGNANCY
1st trimester: Quinidine or Artesunate 2nd – 3rd trimesters: 1. Artesunate 2. Artemether
Treatment for CHEMOPROPHYLAXIS
Chloroquine resistant
Primaquine
Atovaquone-Proguanil (Malarone)
Mefloquine
Doxycycline
CHEMOPROPHYLAXIS for PREGNANCY
Chloroquine resistant
Mefloquine