antilipid pharm

Question 1

Triglycerides

Answer 1

• are esterified fatty acids (FA’s)
  
  • 3 FAs on molecule
• FAs are important source of energy

Question 1

Cholesterol

Answer 1

• is a lipid
• component of cellular membranes
  
  • role=increases fluidity
• precursor of bile acids and steroid hormones
  
  • steroid hormone and gluccocorticoids from adrenal cortex
• Liver is the main source of circulating cholesterol
  
  • Liver and gut also produce
• synthesized from acetyl-CoA
• Total cholesterol levels correlate wtih dietary saturated fat intake NOT dietary cholesteral
• Rate limiting step in cholesterol synthesis is catalyzed by:
  
  • HMG-CoA reductase
  • converts HMG-CoA to mevalonate