Antiinflammatory Drugs Flashcards
Salicylates are:
Block inflammatory response
Antipyretic
Analgesic
All of above
What does salicylate do
Inhibit the synthesis of prostaglandin ,
Block prostaglandin mediator of pyrogens
Affect platelet aggregation by inhibiting the synthesis of thromboxane A2
Salicylates used to treat
Mild to moderate pain
Mild to moderate fever
Treatment of numerous inflammatory condition
Used at low dose prevent risk death and MI
Relief gout and muscular pain
Side effect of salicylates:
Dyspepsia
Ringing in ears
Bleeding
Epigastric discomfort
All of the above
Some sign of salicylate toxicity
Hyperpnea,tachypnea,homorrhage ,metabolic acidioisis
What is the two enzymes that inhibit by NSAIDs
COX-1,COX-2
Indication of NSAIDs
Relief sign and symptom of rheumatoid arthritis and osteoarthritis
Relief mild to moderate pain
Treat primary dysmenorrhea
Fever reduction
Side effect of NSAIDs
Nausea, dyspepsia,GI pain,GI bleeding,increase CV events and death
The most frequently used drug for managing pain and fever in children
Acetoaminophen
How acetoaminophen work
Work on thermoregulatory cell in hypothalamus
Side effect of Acetoaminophen
Hemolytic anemia,hetatotoxicity
Treatment of patient with gold salt
Chrysotherapy
Drug use to treat some cases of rheumatoid ,whose disease have been unresponsive to standards therapy
Gold compound( aurothioglucose)
Side effect of gold compound
Stomatitis,gingivitis,pharyngitis,laryngitis,anaphylactic shock
Example of drug DMARD
Anakinra
