Antiinflammatory drugs Flashcards
Anti-inflammatory and immunosuppressive drugs could act on several pharmacodynamic targets eg membrane receptors, intracellular receptors and enzymes. Choose one drug acting on each target and
a. describe the specific mechanism of action 6p
NSAID (enzyme inhibitors), non-steroidal anti-inflammatory drugs. They are COX inhibitors. Irreversible Treo, reversible ipren.
Glucocorticoids binds to intracellular receptors, receptor ligand complex migrate to nucleus, that affect transcription of genes either up or down regulating.
Cyclosporine is an example of a immunosuppressive drug that inhibit production of IL-2 which results in decreased clonal proliferation of T cells. They wokr on the IL-2 receptor on the cell surface.
Anti-inflammatory and immunosuppressive drugs could act on several pharmacodynamic targets eg membrane receptors, intracellular receptors and enzymes. Choose one drug acting on each target and
b. state a common Type A side effect for each drug (drug group), motivate 3p
Treo and Ipren has aisde effects on the gastic mucosa and platelets.
Glucocorticoids have metabolic effects, increase weight, proness to diabetes etc especially when not administrated locally.
Cycvlosporine increase risk of infections and tumors
Anti-inflammatory drugs could act on several pharmacodynamics targets eg receptors, enzymes or gene transcription.
Choose one drug for each target and;
a. describe the specific mechanism of action
NSAID (enzyme inhibitors), non-steroidal anti-inflammatory drugs. They are COX inhibitors. Irreversible Treo, reversible ipren.
Glucocorticoids binds to intracellular receptors, receptor ligand complex migrate to nucleus, that affect transcription of genes either up or down regulating.
Cyclosporine is an example of a immunosuppressive drug that inhibit production of IL-2 which results in decreased clonal proliferation of T cells. They wokr on the IL-2 receptor on the cell surface.
Anti-inflammatory drugs could act on several pharmacodynamics targets eg receptors, enzymes or gene transcription.
Choose one drug for each target and;
Identify a common Typ A side effect for each drug (drug group), motivate
Treo and Ipren has aisde effects on the gastic mucosa and platelets.
Glucocorticoids have metabolic effects, increase weight, proness to diabetes etc especially when not administrated locally.
Cycvlosporine increase risk of infections and tumors
Anti-inflammatory drugs can use several different cellular targets to induce the antiinflammatory effect
a. Describe the mechanism of action of NSAIDs and explain how this action will
result in reduced inflammation
NSAID (enzyme inhibitors), non-steroidal anti-inflammatory drugs. They are COX inhibitors. Irreversible Treo, reversible ipren.NSAIDs inhibit the activity of both COX-1 and COX-2 enzymes, but they are more selective for COX-2. By inhibiting COX-2 activity, NSAIDs reduce the production of prostaglandins that mediate inflammation and pain, leading to reduced inflammation and pain.
In addition to inhibiting COX activity, some NSAIDs also have other mechanisms of action that contribute to their anti-inflammatory effects. For example, some NSAIDs can inhibit the activation of white blood cells, which are involved in the immune response and the production of pro-inflammatory cytokines. Others may interfere with the production of free radicals or oxidative stress, which are associated with inflammation.
Name and describe the mechanism of action for another antiinflammatory
drug that not belongs to the NSAIDS
Glucocorticoids binds to intracellular receptors, receptor ligand complex migrate to nucleus, that affect transcription of genes either up or down regulating.
Budesonide works by binding to glucocorticoid receptors in the body. This binding causes a decrease in the production of inflammatory mediators such as cytokines and leukotrienes. This reduces inflammation and swelling in the affected area.
Budesonide also has an anti-proliferative effect, which means it can help prevent the growth of certain cells that can cause inflammation. It also has an immunosuppressive effect, which means it can reduce the activity of the immune system and reduce inflammation.
