Antiinfectives

Question 1

What are the 3 clinical signs of bacterial infection?

Answer 1

1. Mucopurulent discharge
2. Diffuese conjunctival injection (entire eye would be infected)
3. Corneal compromise

Question 2

Which drugs are concentration dependent?

Answer 2

Aminoglycosides

Fluroquinolones

Question 3

50% ocular infections caused by?

Answer 3

staph (gram +)

Question 4

Water borne bacteria?

Answer 4

serratia marcesens
pseudomonas aeruginosa (2nd most common nosocomial infection)

Question 5

What are aminopenicillins combined with?

Answer 5

Sulbactam or Cluvulanete since they inhibit PCNase

Question 6

Which antibiotics should be taken on empty stomach?

Answer 6

Penicillins and Tetracycline

Question 7

Name a first generation cephlasporin that would be cross reactive with 15% penicillins?

Answer 7

Cephalexin (500 bid for 7 days eyelid infections)

Question 8

Cell membrane toxins are only available topically due to systemic toxicity ?

Answer 8

True

Question 9

Which protein synthesis inhibitor is a stand alone?

Answer 9

Chloramphenicol (50s)

Question 10

Which bacteria can drill a hole in your eye and which antibiotic does not work against it?

Answer 10

pseudomonas (contact wearers)

Neomycin (amino) oldest aminogly. and never stands alone

Question 11

What is the first and second best options to treat MRSA?

Answer 11

1. Trimethoprim (polytrim)

2. Tobramycin

Question 12

Which class might not be good for dry eye or prophylaxis?

Answer 12

aminoglycoside

Question 13

which class inactivates PCN or cephlaspor.

Answer 13

aminoglycosides

Question 14

Which antibiotics are linked to IIH?

Answer 14

gentamicin (corneal epith toxicity most pronounced)

tetracycline

Question 15

Who should not take tetracycline?

Answer 15

pregnant women
children
nursing mothers
renal failure

Question 16

What increases time on eye when combined with azocite

Answer 16

durasite

Question 17

Which 2 macrolides are class B preg?

Answer 17

E mycin and Az

Question 18

IV immature liver function and cyanosis that develops with Chloramphenicol?

Answer 18

Grey Baby Syndrome

Question 19

Which is available in topical ointment only due to nephrotoxicity?

Answer 19

Bacitracin

Question 20

What do bacteria rely on as a substrate for folic acid metabolism in hibitors

Answer 20

paba

Question 21

Wht blocks the first transition from paba to DHF?

Answer 21

Sulfonnimides (combined with trimenthoprim )

Question 22

Do self work in excess highly muco environment?

Answer 22

no; excess paba in discharge from lot of decying bacteria

Question 23

Wht is drug of choice for pediatric conjunctivitis?

Answer 23

polymyxin B + Trimehoprim

used by homophiles nd strep

Question 24

Folic Cid Inhibitor d adverse Rections

Answer 24

Hypersensitivity
Blood discuss
Sulfonmides
Trimeoprim (bine mrw)

Question 25

Which fluorouinolones drug designed for topic eyesore use that is suspension?

Answer 25

besifloxcin w/ dursite