Antiinfectives Flashcards
What are the 3 clinical signs of bacterial infection?
- Mucopurulent discharge
- Diffuese conjunctival injection (entire eye would be infected)
- Corneal compromise
Which drugs are concentration dependent?
Aminoglycosides
Fluroquinolones
50% ocular infections caused by?
staph (gram +)
Water borne bacteria?
serratia marcesens pseudomonas aeruginosa (2nd most common nosocomial infection)
What are aminopenicillins combined with?
Sulbactam or Cluvulanete since they inhibit PCNase
Which antibiotics should be taken on empty stomach?
Penicillins and Tetracycline
Name a first generation cephlasporin that would be cross reactive with 15% penicillins?
Cephalexin (500 bid for 7 days eyelid infections)
Cell membrane toxins are only available topically due to systemic toxicity ?
True
Which protein synthesis inhibitor is a stand alone?
Chloramphenicol (50s)
Which bacteria can drill a hole in your eye and which antibiotic does not work against it?
pseudomonas (contact wearers)
Neomycin (amino) oldest aminogly. and never stands alone
What is the first and second best options to treat MRSA?
- Trimethoprim (polytrim)
2. Tobramycin
Which class might not be good for dry eye or prophylaxis?
aminoglycoside
which class inactivates PCN or cephlaspor.
aminoglycosides
Which antibiotics are linked to IIH?
gentamicin (corneal epith toxicity most pronounced)
tetracycline
Who should not take tetracycline?
pregnant women
children
nursing mothers
renal failure
What increases time on eye when combined with azocite
durasite
Which 2 macrolides are class B preg?
E mycin and Az
IV immature liver function and cyanosis that develops with Chloramphenicol?
Grey Baby Syndrome
Which is available in topical ointment only due to nephrotoxicity?
Bacitracin
What do bacteria rely on as a substrate for folic acid metabolism in hibitors
paba
Wht blocks the first transition from paba to DHF?
Sulfonnimides (combined with trimenthoprim )
Do self work in excess highly muco environment?
no; excess paba in discharge from lot of decying bacteria
Wht is drug of choice for pediatric conjunctivitis?
polymyxin B + Trimehoprim
used by homophiles nd strep
Folic Cid Inhibitor d adverse Rections
Hypersensitivity
Blood discuss
Sulfonmides
Trimeoprim (bine mrw)
