Antihypertensive Drugs Flashcards

0
Q

antihypertensive drugs

A

medication used to treat hypertension

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1
Q

alpha1 blockers

A

drugs that primarily cause arterial and venous dilation through their action on peripheral sympathetic neutrons

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2
Q

cardiac output

A

the amount of blood ejected from the left ventricle, measured in litres per minute

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3
Q

centrally acting adrenergic drugs

A

drugs that modify the function of the sympathetic nervous system in the brain by stimulating alpha2 receptors; alpha2 receptors are inhibitory in nature and thus have a reverse sympathetic effect and cause decreased blood pressure

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4
Q

essential hypertension

A

elevated systemic arterial pressure for which no cause can be found; also called primary or idiopathic hypertension

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5
Q

hypertension

A

a common, often asymptomatic disorder in which systolic blood pressure persistently exceeds 140 mm Hg and/or diastolic pressure exceeds 90 mm Hg

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6
Q

orthostatic hypotension

A

a common adverse effect of adrenergic blocking drugs involving a sudden drop in blood pressure when a person changes position, especially when rising from a seated or horizontal position

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7
Q

prodrug

A

a drug that is inactive in its given form, and which must be metabolised to its active form in the body, generally by the liver, to be effective

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8
Q

secondary hypertension

A

high blood pressure biased by another disease such as renal, pulmonary, endocrine, or vascular disease

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9
Q

drugs for cardiac factors (heart rate and contractibility)

A

beta blockers, calcium channel blockers, centrally acting adrenergics

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10
Q

drugs for circulating volume (salt and aldosterone)

A

ACE inhibitors, diuretics

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11
Q

drugs for hormones (vasodilators and vasoconstrictors)

A

vasodilators, prostaglandins, ACE inhibitors, calcium channel blockers, angiotensin II blockers

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12
Q

drugs for peripheral sympathetic receptors (constrictors and dilators)

A

receptors: alpha1 blockers and beta blockers

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13
Q

drugs for CNS (centrally acting adrenergics)

A

alpha2

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14
Q

drugs for local (peripherally acting adrenergics)

A

?

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15
Q

antihypertensive drugs: adrenergic drugs

A

centrally and peripherally acting adrenergic blockers; centrally acting alpha2 receptor agonists; peripherally acting alpha1 receptor blockers; peripherally acting beta receptor blockers (beta blockers): cardioselective (beta1 and beta2 receptor blockers) and nonselective (beta1 and beta2 receptor blockers); peripherally acting dual aplha1 and beta receptor blockers

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16
Q

antihypertensive drugs: angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and calcium channel blockers

A

benzothiazepines, dihydropyridines, phenylalkylamines

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17
Q

antihypertensive drugs: diuretics

A

loop diuretics, potassium-sparing diuretics, thiazides and thiazide-like diuretics

18
Q

antihypertensive drugs: vasodilators

A

act directly on vascular smooth muscle cells, not through alpha or beta receptors

19
Q

antihypertensive drugs: direct renin inhibitors

20
Q

ACE inhibitors

A

benazepril [Lotensin], captopril [Capoten], enalapril [Vasotec], fosinopril [Monopril], lisinopril [Prinivil, Zestril], moexipril [Aceon], quinapril [Accupril], ramipril [Altace], trandolapril [Mavik]

21
Q

antihypertensive drugs

A

bosentan, captopril, carvedilol, clonidine, doxazosin, enalapril, eplerenone, hydralazine, losartan, nebivolol, sodium nitroprusside, treprostinil

22
Q

alpha1 blockers

A

drugs that primarily cause arterial and venous dilation through their action on peripheral sympathetic neutrons

23
Q

antihypertensive drugs

A

medication used to treat hypertension

24
cardiac output
the amount of blood ejected from the left ventricle, measured in litres per minute
25
centrally acting adrenergic drugs
drugs that modify the function of the sympathetic nervous system in the brain by stimulating alpha2 receptors; alpha2 receptors are inhibitory in nature and thus have a reverse sympathetic effect and cause decreased blood pressure
26
essential hypertension
elevated systemic arterial pressure for which no cause can be found; also called primary or idiopathic hypertension
27
hypertension
a common, often asymptomatic disorder in which systolic blood pressure persistently exceeds 140 mm Hg and/or diastolic pressure exceeds 90 mm Hg
28
orthostatic hypotension
a common adverse effect of adrenergic blocking drugs involving a sudden drop in blood pressure when a person changes position, especially when rising from a seated or horizontal position
29
prodrug
a drug that is inactive in its given form, and which must be metabolised to its active form in the body, generally by the liver, to be effective
30
secondary hypertension
high blood pressure biased by another disease such as renal, pulmonary, endocrine, or vascular disease
31
drugs for cardiac factors (heart rate and contractibility)
beta blockers, calcium channel blockers, centrally acting adrenergics
32
drugs for circulating volume (salt and aldosterone)
ACE inhibitors, diuretics
33
drugs for hormones (vasodilators and vasoconstrictors)
vasodilators, prostaglandins, ACE inhibitors, calcium channel blockers, angiotensin II blockers
34
drugs for peripheral sympathetic receptors (constrictors and dilators)
receptors: alpha1 blockers and beta blockers
35
drugs for CNS (centrally acting adrenergics)
alpha2
36
drugs for local (peripherally acting adrenergics)
?
37
antihypertensive drugs: adrenergic drugs
centrally and peripherally acting adrenergic blockers; centrally acting alpha2 receptor agonists; peripherally acting alpha1 receptor blockers; peripherally acting beta receptor blockers (beta blockers): cardioselective (beta1 and beta2 receptor blockers) and nonselective (beta1 and beta2 receptor blockers); peripherally acting dual aplha1 and beta receptor blockers
38
antihypertensive drugs: angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and calcium channel blockers
benzothiazepines, dihydropyridines, phenylalkylamines
39
antihypertensive drugs: diuretics
loop diuretics, potassium-sparing diuretics, thiazides and thiazide-like diuretics
40
antihypertensive drugs: vasodilators
act directly on vascular smooth muscle cells, not through alpha or beta receptors
41
antihypertensive drugs: direct renin inhibitors
?
42
ACE inhibitors
benazepril [Lotensin], captopril [Capoten], enalapril [Vasotec], fosinopril [Monopril], lisinopril [Prinivil, Zestril], moexipril [Aceon], quinapril [Accupril], ramipril [Altace], trandolapril [Mavik]
43
antihypertensive drugs
bosentan, captopril, carvedilol, clonidine, doxazosin, enalapril, eplerenone, hydralazine, losartan, nebivolol, sodium nitroprusside, treprostinil