Antihypertensive Agents

Question 0

Hydrochlorothiazide

Answer 0

Thiazide diuretic

• Decreases vascular volume and CO by inhibiting Na-Cl transport in DCT = increased water and Na depletion
• decreases TPR

Question 1

Thiazide diuretics

Answer 1

Hydrochlorothiazide & Chlorthalidone

Question 2

Chlorthalidone

Answer 2

Thiazide diuretic

• Decreases vascular volume and CO by inhibiting Na-Cl transport in DCT = increased water and Na depletion -> reduced calcium thus less vasoconstriction
• decreases TPR

Longer duration of action, more potent

Question 3

Furosemide

Answer 3

Loop diuretic
Decreases CO by reducing volume overload
Blocks Na-Cl-K transporter in ascending Henles loop

Question 4

Spironolactone

Answer 4

K+ sparing diuretics
Good for secondary HTN from hyperadolsterone - blocks aldosterone receptors in collecting ducts
Used as an add on

Question 5

Captopril

Answer 5

ACE inhibitor
Inhibits conversion of Ang I to Ang II
Inhibits degradation of bradykinin
Reduces stimulation of AT1and AT2 receptors
Decreases remodeling and renal dysfunction -use w/diabetes

Question 6

Losartan

Answer 6

Angiotensin receptor blocker

AngII AT1 antagonist